Sex bias in diagnostic delay in bronchiectasis: An analysis of the Spanish Historical Registry of Bronchiectasis

Autores de IIS La Fe

• Rosa María Girón Moreno

  Autor

• Casilda Olveira Fuster

  Autor

• Montserrat Vendrell Relat

  Autor

• 

  Miguel Ángel Martínez García

  Autor

• Luis Borderias Clau

  Autor

• Eva Polverino

  Autor

• Eva Martinez Moragon

  Autor

• Milagros Rocha Barajas

  Autor

Participantes ajenos a IIS La Fe

• de Gracia Roldán J
• de la Rosa, D
• Maiz, L
• Ancochea, J
• Vazquez, L
• Soriano, JB

Grupos

• Neumología

  

  Leader

  Miguel Ángel Martínez García

Abstract

Diagnostic delay is common in most respiratory diseases, particularly in bronchiectasis. However, sex bias in diagnostic delay has not been studied to date. Objective: Assessment of diagnostic delay in bronchiectasis by sex. Methods: The Spanish Historical Registry of Bronchiectasis recruited adults diagnosed with bronchiectasis from 2002 to 2011 in 36 centres in Spain. From a total of 2113 patients registered we studied 2099, of whom 1125 (53.6%) were women. Results: No differences were found for sex or age (61.0 +/- 20.6, p = 0.88) or for localization of bronchiectasis (p = 0.31). Bronchiectasis of unknown aetiology and secondary to asthma, childhood infections and tuberculosis was more common in women (all ps < 0.05). More men than women were chronic obstructive pulmonary disease-related bronchiectasis and colonized by Haemophilus influenzae (p < 0.001 for both). Onset of symptoms was earlier in women. The diagnostic delay for women with bronchiectasis was 2.1 years more than for men (p = 0.001). Discussion: We recorded a substantial delay in the diagnosis of bronchiectasis. This delay was significantly longer in women than in men (>2 years). Independent factors associated with this sex bias were age at onset of symptoms, smoking history, daily expectoration and reduced lung function.

Keywords

• Bronchiectasis; diagnostic delay; gender bias; gender gap; sex bias