1. Inicio
  2. Publicaciones
  3. Very early and early systemic sclerosis in the Spanish scleroderma Registry (RESCLE) cohort

Very early and early systemic sclerosis in the Spanish scleroderma Registry (RESCLE) cohort

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Trapiella-Martínez L
  • Díaz-López JB
  • Caminal-Montero L
  • Tolosa-Vilella C
  • Guillén-Del Castillo A
  • Colunga-Argüelles D
  • Rubio-Rivas M
  • Iniesta-Arandia N
  • Castillo-Palma MJ
  • Sáez-Comet L
  • Egurbide-Arberas MV
  • Ortego-Centeno N
  • Freire M
  • Vargas-Hitos JA
  • Ríos-Blanco JJ
  • Rodríguez-Carballeira M
  • Marín-Ballvé A
  • Chamorro-Fernández AJ
  • Pla-Salas X
  • Madroñero-Vuelta AB
  • Ruiz-Muñóz M
  • Fonollosa-Pla V
  • Simeón-Aznar CP

Grupos

Abstract

Objectives: According to the existence of subclinical organ involvement pre-scleroderma should be divided into two subsets: very early and early disease. Pre-scleroderma patients included in the Spanish Scleroderma Registry (RESCLE) Cohort were reclassified into subsets. Differences were evaluated and the risk of progression to definite systemic sclerosis was estimated. Methods: The characteristics of very early and early SSc patients were compared. A logistic regression model was used to determine the risk factors of progression. Results: 1632 patients were included, 36 (2.2%) in the very early subset and 111 (6.8%) in the early subset. There were no differences in sex, age at disease onset, duration of Raynaud's phenomenon, antinuclear antibodies or capillaroscopic findings. Three (8.3%) very early SSc patients evolved to definite SSc, 2 (5.6%) of them meeting the ACR/EULAR 2013 criteria, unlike 31 (28%) early SSc patients, 20 (24%) of them meeting the criteria (p = 0.034). Digestive involvement was an independent risk factor of progression (OR 17; 95% CI, 6.1-47.2). Conclusions: The classification of early forms of sderoderma identifies patients with different prognostic risk of progression. The evolution to definite SSc is more frequent in early than in very early SSc patients. Digestive involvement is a risk factor of progression. An active assessment of organ damage in preclinical stages allows a correct classification and risk stratification, with implications for monitoring and treatment. (C) 2017 Elsevier B.V. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
1568-9972, 1873-0183

AUTOIMMUNITY REVIEWS  ELSEVIER SCIENCE BV

Tipo:
Review
Páginas:
796-802
PubMed:
28564618
Factor de Impacto:
2,648 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 17

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Keywords

  • Early systemic sclerosis; Very early systemic sclerosis; Pre-scleroderma

Proyectos y Estudios Clínicos

ENSAYO MULTICÉNTRICO, ABIERTO Y CON UN SOLO GRUPO PARA EVALUAR LA EFICACIA, LA FARMACOCINÉTICA, LA SEGURIDAD Y LA TOLERABILIDAD DE IGSC AL 20 % EN SUJETOS CON INMUNODEFICIENCIA PRIMARIA.

Investigador Principal: PEDRO MORAL MORAL

GTI 1503 . 2017

PREVENCIÓN DE EPISODIOS DE TROMBOEMBOLIA - REGISTRO EUROPEO SOBRE TROMBOEMBOLIA VENOSA.

Investigador Principal: JOSÉ ANTONIO TODOLÍ PARRA

DAI-VTE-2013-02 . 2014

ENSAYO CLINICO FASE III, DE GRUPOS PARALELOS, RANDOMIZADO, CONTROLADO CON PLACEBO, DOBLE CIEGO Y MULTICENTRICO, PARA EVALUAR LA EFICACIA Y SEGURIDAD DE LA ADMINISTRACION DE TOCILIZUMAB EN PACIENTES DIAGNOSTICADOS DE ORBITOPATÍA TIROIDEA (OT) MODERADA A SE VERA O QUE AMENAZA LA VISTA, QUE NO HAN RESPONDIDO ADECUADAMENTE AL TRATAMIENTO CON PULSOS DE CORTICOIDES.

Investigador Principal: ENRIQUE ESPAÑA GREGORI

GRC-TCL-2010-01 . 2013

ESTUDIO OBSERVACIONAL TRANSVERSAL SOBRE LA LIMITACIÓN FUNCIONAL Y DE LAS ACTIVIDADES LABORALES Y DE LA VIDA DIARIA EN PACIENTES CON ESCLEROSIS SISTÉMICA QUE PRESENTAN O NO ÚLCERAS DIGITALES - ESTUDIO LAUDES.

Investigador Principal: JOSÉ ANTONIO TODOLÍ PARRA

ACT-NUL-2012-01

Cita

Compartir