Is the C242T Polymorphism of the CYBA Gene Linked with Oxidative Stress-Associated Complications of Prematurity?

Fecha de publicación: 10/12/2017

Autores de IIS La Fe

Máximo Vento Torres

Autor

Participantes ajenos a IIS La Fe

Huizing, MJ
Cavallaro, G
Moonen, RM
Gonzalez-Luis, GE
Mosca, F
Villamor, E

Grupos

Perinatología

Leader

Máximo Vento Torres

Abstract

The C242T polymorphism of CYBA (cytochrome B-245 alpha chain), the gene encoding the p22phox subunit of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, has been linked to several conditions in which oxidative stress plays a pathogenic role. We investigated in a cohort of 451 preterm infants [gestational age (GA) 30 weeks] the association of the polymorphism with the risk of developing neonatal respiratory distress syndrome (RDS), retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), necrotizing enterocolitis, patent ductus arteriosus, or intraventricular hemorrhage. We observed a significant association of the TT/CT genotype with RDS [odds ratio (OR) 2.34, 95% confidence interval (95% CI) 1.28-3.90], ROP (OR 1.72, 95% CI 1.05-2.80), and BPD (OR 1.60, 95% CI 1.05-2.43). When this dominant model was adjusted to account for GA, birth weight, and sex, it remained significant for the three outcomes. This study is the first to address the association of a polymorphism related to the NADPH family with oxidative stress-related complications of prematurity. Since p22phox is essential for reactive oxygen species production by NADPH oxidase, we hypothesize that genetic variations in the protein may lead to differences in susceptibility to oxidative stress-induced damage in preterm infants.

Datos de la publicación

ISSN/ISSNe:: 1523-0864, 1557-7716
Tipo:: Article
Páginas:: 1432-1438
DOI:: 10.1089/ars.2017.7042
Factor de Impacto:: 2,607 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Métricas

Filiaciones

Huizing, MJ:: MUMC, Sch Oncol & Dev Biol GROW, Dept Pediat, Postbus 5800, NL-6202 AZ Maastricht, Netherlands
Cavallaro, G:: 2 Neonatal Intensive Care Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano , Milan, Italy

Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Clin Sci & Community Hlth, Neonatal Intens Care Unit, Milan, Italy
Moonen, RM:: Zuyderland Med Ctr Heerlen, Dept Pediat, Heerlen, Netherlands
Gonzalez-Luis, GE:: 4 Department of Pediatrics, Hospital Universitario Materno-Infantil de Canarias , Las Palmas de Gran Canaria, Spain

Hosp Univ Maternoinfantil Canarias, Dept Pediat, Las Palmas Gran Canaria, Spain
Mosca, F:: 2 Neonatal Intensive Care Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano , Milan, Italy

Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Clin Sci & Community Hlth, Neonatal Intens Care Unit, Milan, Italy
Vento, M:: 5 Department of Neonatology, University and Polytechnic Hospital La Fe , Valencia, Spain

Univ & Polytech Hosp La Fe, Dept Neonatol, Valencia, Spain
Villamor, E:: MUMC, Sch Oncol & Dev Biol GROW, Dept Pediat, Postbus 5800, NL-6202 AZ Maastricht, Netherlands