Portal de investigación
Antineoplastic agents exacerbating Charcot Marie Tooth disease: red flags to avoid permanent disability
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Ibañez-Juliá MJ
- Berzero, G
- Reyes-Botero, G
- Maisonobe, T
- Lenglet, T
- Slim, M
- Louis, S
- Sanson, M
- Le Guern, E
- Latour, P
- Ricard, D
- Stojkovic, T
- Psimaras, D
Grupos
Abstract
Background: Charcot Marie Tooth (CMT) disease is the most common form of hereditary neuropathy. Due to the high prevalence of mild and undiagnosed forms, patients with CMT disease may be exposed to severe neurotoxicity following the administration of neurotoxic chemotherapies. The aim of this report is to alert oncologists to the potential to precipitate severe irreversible peripheral neuropathies when administering neurotoxic compounds to undiagnosed CMT patients.Material and methods: A retrospective research in the OncoNeuroTox database was performed (2010-2016), searching for patients with the diagnosis of chemotherapy-induced peripheral neuropathy (CIPN) and CMT disease. A comprehensive literature review for previously published cases was performed using the Pubmed and Cochrane databases (1972-2017).Results: Among 428 patients with CIPN, we identified eight patients with concomitant CMT disease. Seven patients out of the eight had no previous diagnosis of CMT disease, although accurate familial history disclosed mild signs of peripheral neuropathy in five cases. Patients themselves had minor stigmata of long-standing peripheral damage. Patients received chemotherapy regimens based on vinca alkaloids, taxanes or a combination of vinca alkaloids and platinum compounds. In two cases, cumulative doses were below or equal to the expected neurotoxic threshold. Following chemotherapy administration, patients developed severe length-dependent sensory-motor deficits. Despite early drug discontinuation, most patients remained severely disabled.Conclusion: A brief checklist to disclose long-standing signs of peripheral neuropathy could be helpful to detect patients with undiagnosed hereditary neuropathies who could be at risk of developing severe irreversible neurotoxicity following the administration of neurotoxic agents.
Datos de la publicación
- ISSN/ISSNe:
- 0284-186X, 1651-226X
- Tipo:
- Article
- Páginas:
- 403-411
- PubMed:
- 29243538
- Factor de Impacto:
- 1,222 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
ACTA ONCOLOGICA TAYLOR & FRANCIS LTD
Citas Recibidas en Web of Science: 13
Documentos
- No hay documentos
Filiaciones
Keywords
- INDUCED PERIPHERAL NEUROPATHY; ACUTE LYMPHOBLASTIC-LEUKEMIA; MOTOR SENSORY NEUROPATHY; VINCRISTINE NEUROTOXICITY; HEREDITARY MOTOR; CHEMOTHERAPY; PATIENT; POLYNEUROPATHY; TYPE-1; 1A
Proyectos y Estudios Clínicos
RED TEMATICA DE INVESTIGACION COOPERATIVA EN CANCER (RTICC)
Investigador Principal: MIGUEL ÁNGEL SANZ ALONSO
RD12/0036/0014 . INSTITUTO DE SALUD CARLOS III . 2013
PRIMER ESTUDIO EN PERSONAS CON MEN1112, UN ANTICUERPO MONOCLONAL DIRIGIDO A CD157 EN LEUCEMIA MIELOIDE AGUDA EN RECAÍDA O REFRACTARIA.
Investigador Principal: PAU MONTESINOS FERNÁNDEZ
ARMY-1 . 2015
ESTUDIO DE LAS CARACTERÍSTICAS CLÍNICAS Y BIOLÓGICAS EN PACIENTES CON LINFOMAS B DE ALTO GRADO (TIPO BURKITT Y LINFOMA B CON CARACTERÍSTICAS INTERMEDIAS ENTRE LINFOMA DE BURKITT Y LINFOMA DIFUSO DE CÉLULAS GRANDES B) EN EL CONTEXTO POST-TRASPLANTE.
Investigador Principal: SAMUEL ROMERO DOMÍNGUEZ
GEL-INM-2017-01
EVALUACIÓN DEL MANEJO DE LOS PACIENTES CON LINFOMA CEREBRAL PRIMARIO EN ESPAÑA.
Investigador Principal: AITANA BALAGUER ROSELLÓ
GEL-LCP-2015-01
Cita
Ibañez MJ,Berzero G,Reyes G,Maisonobe T,Lenglet T,Slim M,Louis S,BALAGUER A,Sanson M,Le E,Latour P,Ricard D,Stojkovic T,Psimaras D. Antineoplastic agents exacerbating Charcot Marie Tooth disease: red flags to avoid permanent disability. Acta Oncol. 2018. 57. (3):p. 403-411. IF:3,298. (2).