A randomized trial to compare the efficacy and tolerability of sodium picosulfate-magnesium citrate solution vs. 4 L polyethylene glycol solution as a bowel preparation for colonoscopy

Autores de IIS La Fe

• 

  Vicente Pons Beltrán

  Autor

Participantes ajenos a IIS La Fe

• Munoz-Navas, Miguel
• Luis Calleja, Jose
• Payeras, Guillermo
• Jose Hervas, Antonio
• Esteban Abreu, Luis
• Orive, Victor
• Menchen, Pedro L.
• Maria Bordas, Jose
• Ramon Armengol, Jose
• Carretero, Cristina
• Alonso-Abreu, Inmaculada
• Manteca, Roman
• Parra-Blanco, Adolfo
• Carballo, Fernando
• Manuel Herrerias, Juan
• Badiola, Carlos

Grupos

• Endoscopia Digestiva y Hepática

  

  Leader

  Vicente Pons Beltrán

Abstract

The purpose of this study is to compare the efficacy and acceptability of an evening-before regimens of sodium picosulfate/magnesium citrate (SPMC) and polyethylene glycol (PEG) as bowel cleansers and to explore the results of a same-day regimen of SPMC. Multicenter, randomized, observer-blinded, parallel study carried out in subjects who were 18-80 years old and were undergoing diagnostic colonoscopy for the first time. The primary outcome was treatment success, which was a composite outcome defined by (1) the evaluation of the overall preparation quality as "excellent" or "good" by two blinded independent evaluators with the FleetA (R) Grading Scale for Bowel Cleansing and (2) a subject's acceptability rating of "easy to take" or "tolerable." The primary outcome was analyzed using a logistic regression with site, gender, and age group (age a parts per thousand yen65 years and < 65 years) as factors. Four hundred ninety subjects were included in the efficacy evaluation. Although treatment success was significantly higher in subjects assigned to the evening-before regimen of SPMC vs. subjects assigned to the evening-before PEG, when evaluating the two individual components for treatment success, there were significant differences in the ease of completion but not in the quality of preparation. The same-day SPMC regimen was superior to both the evening-before regimen of SPMC and PEG in terms of the quality of preparation, especially regarding the proximal colon. An evening-before regimen of SPMC is superior to an evening-before regimen of PEG in terms of subject's acceptability. The same-day SPMC regimen provides better cleansing levels in the proximal colon.

Keywords

• Sodium picosulfate/magnesium citrate; Polyethylene glycol; Randomized trial; Bowel cleansing colonoscopy; Same-day bowel preparation