Oxidative stress in Crohn's disease

Autores de IIS La Fe

• Inés Moret Tatay

  Autor

• Elena Cerrillo Bataller

  Autor

• Ana Navarro Puche

  Autor

• Marisa Iborra Colomino

  Autor

• Francisco Rausell Palamos

  Autor

• Luis Tortosa Seguí

  Autor

• Belén Beltrán Niclós

  Autor

Grupos

• Enfermedad Inflamatoria Intestinal

Abstract

Crohn's disease (CD) is characterized by transmural inflammation that is most frequently located in the region of the terminal ileum. Although the physiopathological mechanisms of the disease are not yet well defined, the unregulated immune response is associated with high production of reactive oxygen species (ROS). These elements are associated with complex systems known as antioxidant defenses, whose function is ROS regulation, thereby preventing the harmful effects of these elements. However, the presence of an imbalance between ROS production and ROS elimination by antioxidants has been widely described and leads to oxidative stress. In this article, we describe the most significant findings on oxidative stress in the intestinal mucosa and peripheral blood. (C) 2013 Elsevier Espana, S.L. and AEEH y AEG. All rights reserved.

Keywords

• Oxidative stress; Crohn's disease; Catalase