Possible Biomarkers in Blood for Crohn's Disease: Oxidative Stress and MicroRNAs-Current Evidences and Further Aspects to Unravel

Fecha de publicación: 01/01/2016

Autores de IIS La Fe

Inés Moret Tatay

Autor
Marisa Iborra Colomino

Autor
Elena Cerrillo Bataller

Autor
Luis Tortosa Seguí

Autor
Pilar Nos Mateu

Autor
Belén Beltrán Niclós

Autor

Grupos

Enfermedad Inflamatoria Intestinal

Leader

Pilar Nos Mateu

Abstract

Crohn's disease (CD) is an inflammatory disorder characterised by a transmural inflammation of the intestinal wall. Although the physiopathology of the disease is not yet fully understood, it is clear that the immune response plays an important role in it. This hyperreactive immune system is accompanied by the presence of unregulated reactive oxygen species (ROS). These elements are modulated in normal conditions by different elements, including enzymes that function as antioxidant defences preventing the harmful effects of ROS. However, in CD there is an imbalance between ROS production and these antioxidant elements, resulting in oxidative stress (OxS) phenomena. In fact, now OxS is being considered more a potential etiological factor for Crohn's disease rather than a concomitant effect in the disease. The persistence of the OxS can also be influencing the evolution of the disease. Furthermore, the epigenetic mechanisms, above all microRNAs, are being considered key elements in the pathogenesis of CD. These elements and the presence of OxS have also been linked to several diseases. We, therefore, describe in this review the most significant findings related to oxidative stress and microRNAs profiles in the peripheral blood of CD patients.

Datos de la publicación

ISSN/ISSNe:: 1942-0900, 1942-0994
Tipo:: Review
Páginas:: 2325162-2325162
DOI:: 10.1155/2016/2325162
Factor de Impacto:: 1,547 SCImago ℠
Cuartil:: Q1 SCImago ℠

Documentos

No hay documentos

Métricas

Filiaciones

Moret-Tatay I:: Instituto de Investigación. Inflammatory Bowel Disease Research Group, IIS Hospital La Fe, Avenida Fernado Abril Martorell, No. 106, 46026 Valencia, Spain

CIBERehd, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
Iborra M:: Instituto de Investigación. Inflammatory Bowel Disease Research Group, IIS Hospital La Fe, Avenida Fernado Abril Martorell, No. 106, 46026 Valencia, Spain

Gastroenterology Department, La Fe University and Polytechnic Hospital, Avenida Fernado Abril Martorell, No. 106, 46026 Valencia, Spain
Cerrillo E:: Instituto de Investigación. Inflammatory Bowel Disease Research Group, IIS Hospital La Fe, Avenida Fernado Abril Martorell, No. 106, 46026 Valencia, Spain

Gastroenterology Department, La Fe University and Polytechnic Hospital, Avenida Fernado Abril Martorell, No. 106, 46026 Valencia, Spain
Tortosa L:: Instituto de Investigación. Inflammatory Bowel Disease Research Group, IIS Hospital La Fe, Avenida Fernado Abril Martorell, No. 106, 46026 Valencia, Spain

CIBERehd, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
Nos P:: Instituto de Investigación. Inflammatory Bowel Disease Research Group, IIS Hospital La Fe, Avenida Fernado Abril Martorell, No. 106, 46026 Valencia, Spain

Gastroenterology Department, La Fe University and Polytechnic Hospital, Avenida Fernado Abril Martorell, No. 106, 46026 Valencia, Spain
Beltrán B:: Instituto de Investigación. Inflammatory Bowel Disease Research Group, IIS Hospital La Fe, Avenida Fernado Abril Martorell, No. 106, 46026 Valencia, Spain

Gastroenterology Department, La Fe University and Polytechnic Hospital, Avenida Fernado Abril Martorell, No. 106, 46026 Valencia, Spain

Keywords

INFLAMMATORY-BOWEL-DISEASE; ULCERATIVE-COLITIS; REDOX REGULATION; CIRCULATING MICRORNA; ANTIOXIDANT CAPACITY; LIPID-PEROXIDATION; HYDROGEN-PEROXIDE; DNA-DAMAGE; EXPRESSION; SERUM