Direct association between pharyngeal viral secretion and host cytokine response in severe pandemic influenza.

Autores de IIS La Fe

• Raquel Almansa Mora

  Autor

• Ana Anton Conejero

  Autor

• Paula Ramírez Galleymore

  Autor

• Ignacio Martin Loheches

  Autor

• Julia Blanco Gonzalez

  Autor

• David Andaluz Ojeda

  Autor

• Mónica Gordón Sahuquillo

  Autor

• Victor Fernandez Gallego

  Autor

• María Angeles Marcos Maeso

  Autor

• Jordi Rello Condomines

  Autor

• Jesus Francisco Bermejo Martin

  Autor

Participantes ajenos a IIS La Fe

• Banner D
• Pumarola T
• Xu L
• Ran L
• Lopez-Campos G
• Martin-Sanchez F
• Socias L
• Loza A
• Maravi E
• Gallegos MC
• León C
• Merino P
• Gandía F
• Bobillo F
• Resino S
• Eiros JM
• Castro C
• Mateo P
• Gonzalez-Rivera M
• de Lejarazu RO
• Kelvin DJ

Grupos

• Infecciones Respiratorias

Abstract

Severe disease caused by 2009 pandemic influenza A/H1N1virus is characterized by the presence of hypercytokinemia. The origin of the exacerbated cytokine response is unclear. As observed previously, uncontrolled influenza virus replication could strongly influence cytokine production. The objective of the present study was to evaluate the relationship between host cytokine responses and viral levels in pandemic influenza critically ill patients.