Portal de investigación
Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Feijoo-Bandin, S
- Garcia-Vence, M
- Garcia-Rua, V
Grupos
Abstract
Two-pore channels (TPC1-3) comprise a subfamily of the eukaryotic voltage-gated ion channels (VGICs) superfamily that are mainly expressed in acidic stores in plants and animals. TPCS are widespread across the animal kingdom, with primates, mice and rats lacking TPC3, and mainly act as Ca+ and Na+ channels, although it was also suggested that they could be permeable to other ions. Nowadays, TPCs have been related to the development of different diseases, including Parkinson's disease, obesity or myocardial ischemia. Due to this, their study has raised the interest of the scientific community to try to understand their mechanism of action in order to be able to develop an efficient drug that could regulate TPCs activity. In this review, we will provide an updated view regarding TPCs structure, function and activation, as well as their role in different pathophysiological processes.
Datos de la publicación
- ISSN/ISSNe:
- 1933-6950, 1933-6969
- Tipo:
- Review
- Páginas:
- 20-33
- PubMed:
- 27440385
- Factor de Impacto:
- 0,881 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
Channels TAYLOR & FRANCIS INC
Citas Recibidas en Web of Science: 15
Documentos
- No hay documentos
Filiaciones
Keywords
- endolysosome; NAADP; PI(3,5)P2; TPC1; TPC2
Cita
Feijoo S,Garcia M,Garcia V,Rosello E,Portoles M,Rivera M,Gonzalez JR,Lago F. Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions. Channels. 2017. 11(1):p. 20-33. IF:2,538. (3).