Chronic ethanol consumption enhances interleukin-1-mediated signal transduction in rat liver and in cultured hepatocytes.

Autores de IIS La Fe

• Ana María Blanco Sánchez

  Autor

• Inmaculada Azorín Villena

  Autor

• Margarita Pascual Beltrán

  Autor

• María José Gómez-Lechón Moliner

  Autor

• Jaime Renau Piqueras

  Autor

• Veronica Cynthia Fernandez Aguerriberry

  Autor

Participantes ajenos a IIS La Fe

• Valles SL
• Guasch R

Abstract

Interleukin-1 (IL-1) is a central mediator of the inflammatory process. Increased serum levels of IL-1 have been reported in alcoholics with liver damage, but it remains unknown whether chronic ethanol intake, in the presence or absence of lipopolysaccharide (LPS), activates IL-1 release and signaling in the hepatocyte.

Keywords

• alcoholic liver disease; NF kappa B; IL-1 beta; IRAK; ERK1/2