MAGE-A1 expression is associated with good prognosis in neuroblastoma tumors.

Autores de IIS La Fe

• Elena Grau García

  Autor

• Juan Silvestre Oltra Soler

  Autor

• 

  Francisco Martínez Castellano

  Autor

• Carmen Orellana Alonso

  Autor

• Adela Cañete Nieto

  Autor

• José María Fernández Navarro

  Autor

• Miguel Jose Hernandez Marti

  Autor

• Victoria Castel Sánchez

  Autor

Grupos

• 

  Biomedicina Molecular, Celular y Genómica

• Investigación Clínica y Traslacional en Cáncer

Abstract

Neuroblastoma is an embryonal tumor of neuroectodermal cells. Patients with metastatic neuroblastoma have a poor survival rate, which has led to numerous efforts to develop prognostic markers. Cancer/testis-specific antigens MAGE-A1 and MAGE-A3 genes were proposed as minimal residual disease (MRD) markers in neuroblastoma, but its usefulness for this purpose is rather limited.