ABO incompatibility does not influence transfusion requirements in patients undergoing single-unit umbilical cord blood transplantation

Autores de IIS La Fe

• Pilar Solves Alcaina

  Autor

• Nelly Carpio Martinez

  Autor

• Carlos Carretero Marquez

  Autor

• Jose Ignacio Lorenzo Herrero

  Autor

• Jaime Sanz Caballer

  Autor

• Inés Gómez Seguí

  Autor

• Francisca Lopez Chulia

  Autor

• María Jesus Arilla Morell

  Autor

• Ana Isabel Regadera Gonzalez

  Autor

• Pau Montesinos Fernández

  Autor

• Guillermo Sanz Santillana

  Autor

• Miguel Ángel Sanz Alonso

  Autor

Grupos

• Hematología y Hemoterapia

Abstract

Hematopoietic stem cell transplantation is usually performed without considering the ABO compatibility between donor and recipient. There are few studies analyzing ABO matching impact on transfusion outcome of umbilical cord blood transplantation (UCBT) recipients. The aim of this study was to analyze factors influencing transfusion outcome, highlighting the ABO matching between donor and recipient. This study has reviewed data from 318 patients who underwent single unit UCBT at la Fe University Hospital from January 2000 to December 2014. There were no differences between RBC and platelet (PLT) requirements or RBC and PLT transfusion independence according to ABO matching between donor and recipient. RBC and PLT requirements were statistically correlated (rho = 0,841, Po0.001). A total of 170 and 188 patients achieved RBC and PLT independence, respectively, within 180 days after UCBT. Persistence of recipient isoagglutinins was detected in 6.8% of patients with major ABO incompatibility at median of 176 days (103-269) after UCBT. Autoimmune haemolytic anemia was diagnosed in 15 patients, 12 of them due to cold antibodies. In conclusion, ABO matching has not influenced transfusion requirements of patients undergoing UCBT.