Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

Fecha de publicación: 26/01/2017

Autores de IIS La Fe

Miguel Ángel Sanz Alonso

Autor

Participantes ajenos a IIS La Fe

Döhner H
Estey, E
Grimwade, D
Amadori, S
Appelbaum, FR
Buchner, T
Dombret, H
Ebert, BL
Fenaux, P
Larson, RA
Levine, RL
Lo-Coco, F
Naoe, T
Niederwieser, D
Ossenkoppele, GJ
Sierra, J
Tallman, MS
Tien, HF
Wei, AH
Löwenberg B
Bloomfield, CD

Grupos

Hematología y Hemoterapia

Investigador Principal

Javier De La Rubia Comos

Abstract

The first edition of the European LeukemiaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults, published in 2010, has found broad acceptance by physicians and investigators caring for patients with AML. Recent advances, for example, in the discovery of the genomic landscape of the disease, in the development of assays for genetic testing and for detecting minimal residual disease (MRD), as well as in the development of novel antileukemic agents, prompted an international panel to provide updated evidence-and expert opinion-based recommendations. The recommendations include a revised versionof theELNgenetic categories, a proposal for a response category based on MRD status, and criteria for progressive disease.

Datos de la publicación

ISSN/ISSNe:: 0006-4971, 1528-0020
Tipo:: Review
Páginas:: 424-447
DOI:: 10.1182/blood-2016-08-733196
Factor de Impacto:: 6,434 SCImago ℠
Cuartil:: Q1 SCImago ℠

Documentos

No hay documentos

Métricas

Filiaciones

Döhner H:: Department of Internal Medicine III, University of Ulm, Ulm, Germany
Estey, E:: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA

Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA
Grimwade, D:: Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom

Kings Coll London, Fac Life Sci & Med, Dept Med & Mol Genet, London, England
Amadori, S:: Department of Biomedicine and Prevention, Università di Roma "Tor Vergata," Rome, Italy

Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy
Appelbaum, FR:: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA

Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA
Buchner, T:: Department of Hematology/Oncology, University of Münster, Münster, Germany

Univ Munster, Dept Hematol Oncol, Munster, Germany
Dombret, H:: Institut Universitaire d'Hématologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France

Hop St Louis, AP HP, Inst Univ Hematol, Paris, France
Ebert, BL:: Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

Harvard Med Sch, Brigham & Womens Hosp, Div Hematol, Dept Med, Boston, MA USA
Fenaux, P:: Service d'Hématologie, Hôpital Saint-Louis, Paris, France

Hop St Louis, Serv Hematol, Paris, France
Larson, RA:: Department of Medicine, University of Chicago, Chicago, IL

Univ Chicago, Dept Med, 5841 S Maryland Ave, Chicago, IL 60637 USA
Levine, RL:: Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, 1275 York Ave, New York, NY 10021 USA
Lo-Coco, F:: Department of Biomedicine and Prevention, Università di Roma "Tor Vergata," Rome, Italy

Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy
Naoe, T:: National Hospital Organization Nagoya Medical Center, Nagoya, Japan

Natl Hosp Org, Nagoya Med Ctr, Nagoya, Aichi, Japan
Niederwieser, D:: Department of Hematology, Oncology and Hemostasis, University of Leipzig, Leipzig, Germany

Univ Leipzig, Dept Hematol Oncol & Hemostasis, Leipzig, Germany
Ossenkoppele, GJ:: Department of Haematology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands

Vrije Univ, Univ Med Ctr, Dept Haematol, Amsterdam, Netherlands
Sanz, M:: Department of Hematology, University Hospital La Fe, University of Valencia, Valencia, Spain

Univ Valencia, Univ Hosp La Fe, Dept Hematol, Valencia, Spain
Sierra, J:: Hematology Department, Hospital de la Santa Creu i Sant Pau, Jose Carreras Leukemia Research Institute, Barcelona, Spain

Hosp Santa Creu & Sant Pau, Dept Hematol, Jose Carreras Leukemia Res Inst, Barcelona, Spain
Tallman, MS:: Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, 1275 York Ave, New York, NY 10021 USA
Tien, HF:: Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

Natl Taiwan Univ Hosp, Dept Internal Med, Div Hematol, Taipei, Taiwan
Wei, AH:: Department of Clinical Hematology, The Alfred Hospital, Melbourne, Australia

Australian Centre for Blood Diseases, Monash University, Melbourne, Australia

Alfred Hosp, Dept Clin Hematol, Melbourne, Vic, Australia

Monash Univ, Australian Ctr Blood Dis, Melbourne, Vic, Australia
Löwenberg B:: Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Bloomfield, CD:: The Ohio State University Comprehensive Cancer Center, Columbus, OH

Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

Keywords

ACUTE MYELOID-LEUKEMIA; STEM-CELL TRANSPLANTATION; MINIMAL RESIDUAL DISEASE; ACUTE MYELOGENOUS LEUKEMIA; HIGH-DOSE CYTARABINE; CONVENTIONAL CARE REGIMENS; SINGLE CEBPA MUTATIONS; 1ST COMPLETE REMISSION; RANDOMIZED PHASE-III; BUSULFAN PLUS CYCLOPHOSPHAMIDE

Campos de estudio

Proyectos asociados

RED DE INVESTIGACION COOPERATIVA DE CANCER

RD06/0020/0031 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2006

PROYECTO CAIBER

CAI08/01/0061 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2009

CREACION Y MEJORA DE INFRAESTRUCTURAS EN MEDICINA REGENERATIVA

Investigador Principal: FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA

PLE2009-0141 ACI-PLAN E . MINISTERIO DE CIENCIA E INNOVACION; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2009