Evidence of Wallerian degeneration in normal appearing white matter in the early stages of relapsing-remitting multiple sclerosis: a HMRS study.

Autores de IIS La Fe

• Bonaventura Casanova Estruch

  Autor

• María Carmen Martínez Bisbal

  Autor

• Caridad Valero Merino

  Autor

• 

  Luis Martí Bonmatí

  Autor

• Ana Maria Pascual Lozano

  Autor

• Francisco Coret Ferrer

  Autor

Participantes ajenos a IIS La Fe

• Celda B
• Landente L

Abstract

Wallerian degeneration in normal appearing white matter in early relapsing-remitting multiple sclerosis (RRMS), and its correlation with the number of relapses and disease duration. Background Recent pathological studies have demonstrated Wallerian degeneration in normal appearing white matter (NAWM) in multiple sclerosis (MS), in established RRMS, and in chronic MS. However, the presence of Wallerian degeneration early in the disease and its correlation with relapse and with disease duration has not been studied.