Portal de investigación
Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Grover A
- Thongjuea S
- Carrelha J
- Giustacchini A
- Gambardella A
- Macaulay I
- Mancini E
- Luis TC
- Mead A
- Jacobsen SE
- Nerlov C
Grupos
Abstract
Aged haematopoietic stem cells (HSCs) generate more myeloid cells and fewer lymphoid cells compared with young HSCs, contributing to decreased adaptive immunity in aged individuals. However, it is not known how intrinsic changes to HSCs and shifts in the balance between biased HSC subsets each contribute to the altered lineage output. Here, by analysing HSC transcriptomes and HSC function at the single-cell level, we identify increased molecular platelet priming and functional platelet bias as the predominant age-dependent change to HSCs, including a significant increase in a previously unrecognized class of HSCs that exclusively produce platelets. Depletion of HSC platelet programming through loss of the FOG-1 transcription factor is accompanied by increased lymphoid output. Therefore, increased platelet bias may contribute to the age-associated decrease in lymphopoiesis.
Datos de la publicación
- ISSN/ISSNe:
- 2041-1723, 2041-1723
- Tipo:
- Article
- Páginas:
- 11075-11075
- DOI:
- 10.1038/ncomms11075
- PubMed:
- 27009448
- Factor de Impacto:
- 6,414 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
NATURE COMMUNICATIONS NATURE PUBLISHING GROUP
Citas Recibidas en Web of Science: 265
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- No hay documentos
Filiaciones
Campos de Estudio
Cita
Grover A,SANJUAN A,Thongjuea S,Carrelha J,Giustacchini A,Gambardella A,Macaulay I,Mancini E,Luis TC,Mead A,Jacobsen SE,Nerlov C. Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells. Nat. Commun. 2016. 7. p. 11075-11075. IF:12,124. (1).