Thrombin-Responsive Gated Silica Mesoporous Nanoparticles As Coagulation Regulators

Autores de IIS La Fe

• Angela Ribes Momparler

  Autor

• Elena Aznar Gimeno

  Autor

• Félix Sancenón Galarza

  Autor

• María Dolores Marcos Martínez

  Autor

• José Ramón Murguía Ibáñez

  Autor

• Ramón Martínez Máñez

  Autor

Participantes ajenos a IIS La Fe

• Bhat R
• Mas N
• Venkataraman A

Grupos

• Unidad Mixta de Investigación en Nanomedicina y Sensores

Abstract

The possibility of achieving sophisticated actions in complex biological environments using gated nanoparticles is an exciting prospect with much potential. We herein describe new gated mesoporous silica nanoparticles (MSN) loaded with an anticoagulant drug and capped with a peptide containing a thrombin-specific cleavage site. When the coagulation cascade was triggered, active thrombin degraded the capping peptidic sequence and induced the-release of anticoagulant drugs to delay the clotting process. The thrombin-dependent response was assessed and a significant increase in coagulation time in plasma from 2.6 min to 5 min was found. This work broadens the application of gated silica nanoparticles and demonstrates their ability to act as controllers in a complex scenario such as hemostasis.