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Surface Enhanced Raman Scattering and Gated Materials for Sensing Applications: The Ultrasensitive Detection of Mycoplasma and Cocaine

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Oroval M
  • Coronado-Puchau M
  • Langer J
  • Sanz-Ortiz MN
  • Coll C
  • Liz-Marzán LM

Grupos

Abstract

We present herein a novel combination of gated mesoporous silica nanoparticles (MSNs) and surface-enhanced Raman scattering (SERS) for sensing applications. As a proof-of-concept, we show the design of a system comprising MSNs loaded with crystal violet (CV), a molecule with high Raman cross section acting as SERS reporter, and capped with either a suitable DNA sequence for the detection of Mycoplasma genomic DNA or with an aptamer that selectively coordinates cocaine. In both cases the presence of the corresponding target analyte in solution (i.e., genomic DNA or cocaine) resulted in the release of CV. CV delivery was detected by SERS upon adsorption on gold nanotriangles (AuNTs), which display an efficient electromagnetic field enhancement and a high colloidal stability. By using this novel procedure a limit of detection of at least 30 copies DNA per L was determined for the detection of Mycoplasma genomic DNA, whereas cocaine was detected at concentrations as low as 10nm.

Datos de la publicación

ISSN/ISSNe:
0947-6539, 1521-3765

CHEMISTRY-A EUROPEAN JOURNAL  WILEY-V C H VERLAG GMBH

Tipo:
Article
Páginas:
13488-13495
PubMed:
27505065
Factor de Impacto:
2,352 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 21

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Keywords

  • biosensors; cocaine; gated materials; Mycoplasma; surface enhanced Raman spectroscopy

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