Assessment of phospholipid synthesis related biomarkers for perinatal asphyxia: a piglet study

Fecha de publicación: 10/01/2017

Autores de IIS La Fe

Ángel Sánchez Illana

Autor
Isabel Lliso Escudero

Autor
Guillermo Quintas Soriano

Autor
Máximo Vento Torres

Autor
Julia Kuligowski

Autor

Participantes ajenos a IIS La Fe

Solberg, R
Pankratov, L
Saugstad, OD

Grupos

Perinatología

Leader

Máximo Vento Torres

Abstract

The prompt and reliable identification of infants at risk of hypoxic-ischemic encephalopathy secondary to perinatal asphyxia in the first critical hours is important for clinical decision-making and yet still remains a challenge. This work strives for the evaluation of a panel of metabolic biomarkers that have been associated with the hypoxic-ischemic insult in the perinatal period. Plasma and urine samples from a consolidated newborn piglet model of hypoxia and withdrawn before and at different time points after a hypoxic insult were analyzed and compared to a control group. Time-dependent metabolic biomarker profiles were studied and observed patterns were similar to those of lactate levels, which are currently considered the gold standard for assessing hypoxia. Class prediction performance could be improved by the use of a combination of the whole panel of determined metabolites in plasma as compared to lactate values. Using a multivariate model including lactate together with the studied metabolic biomarkers allowed to improve the prediction performance of duration of hypoxia time, which correlates with the degree of brain damage. The present study evidences the usefulness of choline and related metabolites for improving the early assessment of the severity of the hypoxic insult.

Datos de la publicación

ISSN/ISSNe:: 2045-2322, 2045-2322
Tipo:: Article
Páginas:: 40315-40315
DOI:: 10.1038/srep40315
PubMed:: 28071721
Factor de Impacto:: 1,533 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Métricas

Filiaciones

Sanchez-Illana, A:: Instituto de Investigación. Neonatal Research Group, Health Research Institute Hospital La Fe, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain

Instituto de Investigación. Hosp La Fe, Hlth Res Inst, Neonatal Res Grp, Ave Fernando Abril Martorell 106, Valencia 46026, Spain
Solberg, R:: Department of Pediatric Research, Institute for Surgical Research, University of Oslo, Oslo University Hospital - Rikshospitalet, Sognsvannsveien 20, 0372 Oslo, Norway

Pediatric Department, Vestfold Hospital Trust, Halfdan Wilhelmsens allé 17, 3103 Tønsberg, Norway

Univ Oslo, Oslo Univ Hosp, Rikshosp, Dept Pediat Res,Inst Surg Res, Sognsvannsveien 20, N-0372 Oslo, Norway

Vestfold Hosp Trust, Pediat Dept, N-3103 Tonsberg, Norway
Lliso, I:: Instituto de Investigación. Neonatal Research Group, Health Research Institute Hospital La Fe, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain

Instituto de Investigación. Hosp La Fe, Hlth Res Inst, Neonatal Res Grp, Ave Fernando Abril Martorell 106, Valencia 46026, Spain
Pankratov, L:: Department of Pediatric Research, Institute for Surgical Research, University of Oslo, Oslo University Hospital - Rikshospitalet, Sognsvannsveien 20, 0372 Oslo, Norway

Univ Oslo, Oslo Univ Hosp, Rikshosp, Dept Pediat Res,Inst Surg Res, Sognsvannsveien 20, N-0372 Oslo, Norway
Quintas, G:: Human &Environmental Health &Safety (HEHS), Leitat Technological Center, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain

Instituto de Investigación. Unidad Analítica, Health Research Institute La Fe, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain

Leitat Technol Ctr, HEHS, Ave Fernando Abril Martorell 106, Valencia 46026, Spain

Instituto de Investigación. Hlth Res Inst La Fe, Unidad Analit, Ave Fernando Abril Martorell 106, Valencia 46026, Spain
Saugstad, OD:: Department of Pediatric Research, Institute for Surgical Research, University of Oslo, Oslo University Hospital - Rikshospitalet, Sognsvannsveien 20, 0372 Oslo, Norway

Univ Oslo, Oslo Univ Hosp, Rikshosp, Dept Pediat Res,Inst Surg Res, Sognsvannsveien 20, N-0372 Oslo, Norway
Vento, M:: Instituto de Investigación. Neonatal Research Group, Health Research Institute Hospital La Fe, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain

Division of Neonatology, University &Polytechnic Hospital La Fe, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain

Instituto de Investigación. Hosp La Fe, Hlth Res Inst, Neonatal Res Grp, Ave Fernando Abril Martorell 106, Valencia 46026, Spain

Univ & Polytech Hosp La Fe, Div Neonatol, Ave Fernando Abril Martorell 106, Valencia 46026, Spain
Kuligowski, J:: Instituto de Investigación. Neonatal Research Group, Health Research Institute Hospital La Fe, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain

Instituto de Investigación. Hosp La Fe, Hlth Res Inst, Neonatal Res Grp, Ave Fernando Abril Martorell 106, Valencia 46026, Spain