P-glycoprotein expression and prognostic value in acute myeloid leukemia.

Autores de IIS La Fe

• María Leonor Senent Peris

  Autor

• Isidro Jarque Ramos

  Autor

• Guillermo Martin Aragones

  Autor

• Amparo Sempere Talens

  Autor

• Jorge Gonzalez Garcia

  Autor

• Federico Gomis Bernal

  Autor

• María Luz Perez Sirvent

  Autor

• 

  Javier De La Rubia Comos

  Autor

• Miguel Ángel Sanz Alonso

  Autor

Abstract

Drug resistance has become a major cause of treatment failure in patients with acute leukemia. P-glycoprotein (Pgp), which is associated with the multidrug resistance (MDR) phenotype, has been reported to be an important predictor of treatment outcome. The aim of this study was to analyze the value of Pgp expression in bone marrow or peripheral blood as a predictor of the response to remission induction chemotherapy as well as the duration of remission in patients with de novo acute myeloid leukemia (AML).