Cannabinoid type 2 receptor activation downregulates stroke-induced classic and alternative brain macrophage/microglial activation concomitant to neuroprotection.

Autores de IIS La Fe

• Jose Luis Vivancos Bono

  Autor

• Raquel Nombela Núñez

  Autor

• Monica Torres Contell

  Autor

• María Consuelo Burguete López

  Autor

• Jorge Manzanares Robles

  Autor

Participantes ajenos a IIS La Fe

• Zarruk JG
• Fernández-López D
• García-Yébenes I
• García-Gutiérrez MS
• Lizasoain I
• Moro MA

Abstract

Ischemic stroke continues to be one of the main causes of death worldwide. Inflammation accounts for a large part of damage in this pathology. The cannabinoid type 2 receptor (CB2R) has been proposed to have neuroprotective properties in neurological diseases. Therefore, our aim was to determine the effects of the activation of CB2R on infarct outcome and on ischemia-induced brain expression of classic and alternative markers of macrophage/microglial activation.

Keywords

• ischemic stroke; MCAO; mouse; cannabinoid; microglia; alternative phenotype