Portal de investigación
Acute cellular rejection versus recurrent hepatitis C after liver transplantation: Clinical and pathological features driving a rational diagnostic approach
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- de la Peña-Moral JM
- Tome S
- Gude F
- Miras M
- Bermejo J
- Varo E
- Parrilla P
Grupos
Abstract
AimThe aim of our study was develop and validate an algorithm system based on morphological features for finding the differences between recurrent hepatitis C virus (HCV) and acute cellular rejection (ACR) in liver biopsies of HCV-transplanted patients. MethodsTwo hundred and eighty-eight liver biopsies were analyzed from 121 patients transplanted for HCV. A diagnostic consensus was reached between clinicians and pathologists in 214 biopsies for the diagnosis of recurrent HCV or ACR. A random sample of 114 liver biopsies (derivation cohort) was taken to generate the diagnostic tree and was subsequently evaluated using the validation cohort in 100 liver biopsies by recursive partitioning analysis of morphological variables and time since transplantation. ResultsThe presence of endotheliitis together with a time of less than 6 weeks since LT definitely excluded recurrent HCV. After obtaining the regression tree, diagnostic accuracy was 96% and 93% in the derivation and validation cohort, respectively. Both cases surpassed the pathologist's original diagnosis, which had a diagnostic accuracy of 91% (P<0.05, for both comparisons). ConclusionA recursive partitioning analysis of the morphological features in liver biopsies from HCV-transplanted patients may be useful for easily distinguishing between recurrent HCV and ACR.
Datos de la publicación
- ISSN/ISSNe:
- 1386-6346, 1872-034X
- Tipo:
- Article
- Páginas:
- 423-431
- DOI:
- 10.1111/hepr.12369
- PubMed:
- 24906075
- Factor de Impacto:
- 0,822 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
HEPATOLOGY RESEARCH WILEY-BLACKWELL
Citas Recibidas en Web of Science: 3
Documentos
- No hay documentos
Filiaciones
Keywords
- acute cellular rejection; algorithm system; liver biopsy; liver transplantation; recurrent hepatitis C
Campos de Estudio
Cita
de la Peña JM,PONS JA,Tome S,Gude F,Miras M,Bermejo J,RAMIREZ P,BERENGUER M,Varo E,FORTEZA J,Parrilla P. Acute cellular rejection versus recurrent hepatitis C after liver transplantation: Clinical and pathological features driving a rational diagnostic approach. Hepatol. Res. 2015. 45. (4):p. 423-431. IF:2,208. (3).