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Experience with Teduglutide in Pediatric Short Bowel Syndrome: First Real-life Data

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Boluda E.R.
  • Ferreiro S.R.
  • Moral O.M.
  • García Romero R.
  • Terradillos I.I.
  • Nuñez Ramos R.
  • Díaz M.G.
  • Piñera I.V.
  • Sánchez A.A.
  • Sacristán R.G.
  • Barea M.B.
  • Villares J.M.M.

Grupos

Abstract

Objectives:The aim of the study was to describe the experience with teduglutide of several Spanish hospitals in pediatric patients with SBS (SBS).Methods:Seventeen pediatric patients with intestinal failure associated with SBS were treated with teduglutide. Patients received 0.05mg·kg-1·day-1of subcutaneous teduglutide. Patients' demographics and changes in parenteral nutrition (PN) needs, fecal losses, and citrulline level initially and at 3, 6, and 12 months were collected, as well as any adverse events.Results:Patients were receiving 55ml·kg-1·day-1and 33kcal·kg-1·day-1of parenteral supplementation on average at baseline (2 patients received only hydroelectrolytic solution). A total of 12/17 patients achieved parenteral independence: 3 patients after 3 months of treatment, 4 patients at 6 months, and 5 after 12 months. One patient discontinued treatment 1 year after the beginning as no changes in parenteral support or fecal losses were obtained. All others decreased their intravenous requirements by 50%. One patient suffered an episode of cholecystitis, and another one with a pre-existing cardiac disease, developed a cardiac decompensation.Conclusions:Teduglutide seems to be a safe and effective treatment in the pediatric SBS population with better results than in the pivotal study as well as in the adult population. © 2020 Lippincott Williams and Wilkins. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0277-2116, 1536-4801

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION  WILEY

Tipo:
Article
Páginas:
734-739
PubMed:
32804906
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
1,206 SCImago ℠
Cuartil:
Q1 SCImago ℠

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Keywords

  • Adult; Child; Gastrointestinal Agents; Humans; Parenteral Nutrition; Peptides; Short Bowel Syndrome; gastrointestinal agent; peptide; teduglutide; adult; child; human; parenteral nutrition; short bowel syndrome

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