Boosting the sensitivity ofin vitroß-lactam allergy diagnostic tests

Autores de IIS La Fe

• Sergi Morais Ezquerro

  Autor

• Ángel Maquieira Catalá

  Autor

Participantes ajenos a IIS La Fe

• Peña-Mendizabal E.

Grupos

• Unidad Mixta de Investigación en Nanomedicina y Sensores

Abstract

The synthesis of structurally new haptens and the development of suitable antigens are essential for boosting the sensitivity of drug allergy diagnostic testing. Unprecedented structural antigens for benzylpenicillin and amoxicillin are characterised and evaluated in a cohort of 70 subjects with a turnkey solution based on consumer electronics. © The Royal Society of Chemistry 2020.

Keywords

• Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Aztreonam; beta-Lactams; Carbonates; Cohort Studies; Diagnostic Tests, Routine; Diamines; Drug Hypersensitivity; Female; Haptens; Humans; Lactams; Male; Middle Aged; Penicillin G; Serum Albumin, Human; Structure-Activity Relationship; Substrate Specificity; Allergies; amoxicillin; penicillin G; amoxicillin; antiinfective agent; aztreonam; beta lactam; carbonic acid; diamine; hapten; human serum albumin; lactam; penicillin G; sodium carbonate; Amoxicillin; Benzylpenicillin; Diagnostic testing; Diagnostic tests; Drug-allergy; allergy; Article; cohort analysis; colorimetry; conjugation; controlled study; diagnostic test; diagnostic test accuracy study; drug screening; drug sensitivity; drug structure; drug synthesis; human; in vitro study; major clinical study; sensitivity and specificity; adult; aged; chemistry; diagnostic test; drug hypersensitivity; enzyme specificity; female; male; metabolism; middle aged; procedures;