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Quality of Life and the Experience of Living with Early-Stage Alzheimer's Disease

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Villarejo-Galende A.
  • García-Arcelay E.
  • Piñol-Ripoll G.
  • Del Olmo-Rodríguez A.
  • Viñuela F.
  • Boada M.
  • Franco-Macías E.
  • Ibañez De La Peña A.
  • Riverol M.
  • Puig-Pijoan A.
  • Abizanda-Soler P.
  • Arroyo R.
  • Feria-Vilar I.
  • Balasa M.
  • Berbel Á.
  • Rodríguez-Rodríguez E.
  • Vieira-Campos A.
  • García-Ribas G.
  • Rodrigo-Herrero S.
  • Terrancle Á.
  • Prefasi D.
  • Lleó A.
  • Maurino J.
  • Clements-Cortes A.

Grupos

Abstract

Background: There is a need to better understand the experience of patients living with Alzheimer's disease (AD) in the early stages. Objective: The aim of the study was to evaluate the perception of quality of life in patients with early-stage AD. Methods: A multicenter, non-interventional study was conducted including patients of 50-90 years of age with prodromal or mild AD, a Mini-Mental State Examination (MMSE) score =22, and a Clinical Dementia Rating-Global score (CDR-GS) of 0.5.-1.0. The Quality of Life in Alzheimer 's Disease (QoL-AD) questionnaire was used to assess health-related quality of life. A battery of self-report instruments was used to evaluate different psychological and behavioral domains. Associations between the QoL-AD and other outcome measures were analyzed using Spearman's rank correlations. Results: A total of 149 patients were included. Mean age (SD) was 72.3 (7.0) years and mean disease duration was 1.4 (1.8) years. Mean MMSE score was 24.6 (2.1). The mean QoL-AD score was 37.9 (4.5). Eighty-three percent (n = 124) of patients had moderate-to-severe hopelessness, 22.1% (n = 33) had depressive symptoms, and 36.9% (n = 55) felt stigmatized. The quality of life showed a significant positive correlation with self-efficacy and negative correlations with depression, emotional and practical consequences, stigma, and hopelessness. Conclusion: Stigma, depressive symptoms, and hopelessness are frequent scenarios in AD negatively impacting quality of life, even in a population with short disease duration and minimal cognitive impairment. © 2022 - The authors. Published by IOS Press.

Datos de la publicación

ISSN/ISSNe:
1387-2877, 1875-8908

JOURNAL OF ALZHEIMERS DISEASE  SAGE PUBLICATIONS LTD

Tipo:
Article
Páginas:
719-726
PubMed:
36155523
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
1,225 SCImago ℠
Cuartil:
Q1 SCImago ℠

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Keywords

  • Aged; Alzheimer Disease; Cognitive Dysfunction; Humans; Quality of Life; Self Report; Surveys and Questionnaires; aged; Alzheimer disease; Article; beck depression inventory fast screen; Beck Hopelessness Scale; clinical assessment tool; clinical dementia rating scale; cross-sectional study; dementia assessment; depression; depression assessment; disease duration; disease severity; female; functional activity questionnaire; functional assessment; General Self-Efficacy Scale; hopelessness; human; major clinical study; male; Mini Mental State Examination; multicenter study; personal experience; psychologic assessment; quality of life; quality of life assessment; quality of life in alzheimer disease questionnaire; representation and adjustment to dementia index; Satisfaction with Life Scale; self concept; self report; social stigma; stigma scale for chronic illness; clinical trial; cognitive defect; psychology; quality of life; questionnaire

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