Supportive care in pediatric acute myeloid leukemia:Expert-based recommendations of the NOPHO-DB-SHIP consortium

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Arad-Cohen N.
  • Zeller B.
  • Abrahamsson J.
  • Cheuk D.
  • Palmu S.
  • Costa V.
  • De Moerloose B.
  • Hasle H.
  • Jahnukainen K.
  • Pronk C.J.
  • Gísli Jónsson Ó.
  • Kovalova Z.
  • Lausen B.
  • Munthe-Kaas M.
  • Noren-Nyström U.
  • Palle J.
  • Pasauliene R.
  • Saks K.
  • Kaspers G.J.L.

Grupos

Abstract

Introduction: Pediatric acute myeloid leukemia (AML) is the second most common type of pediatric leukemia. Patients with AML are at high risk for several complications such as infections, typhlitis, and acute and long-term cardiotoxicity. Despite this knowledge, there are no definite supportive care guidelines as to what the best approach is to manage or prevent these complications. Area covered: The NOPHO-DB-SHIP (Nordic-Dutch-Belgian-Spain-Hong-Kong-Israel-Portugal) consortium, in preparation for a new trial in pediatric AML patients, had dedicated meetings for supportive care. In this review, the authors discuss the available data and outline recommendations for the management of children and adolescents with AML with an emphasis on hyperleukocytosis, tumor lysis syndrome, coagulation abnormalities and bleeding, infection, typhlitis, malnutrition, cardiotoxicity, and fertility preservation. Expert opinion: Improved supportive care has significantly contributed to increased cure rates. Recommendations on supportive care are an essential part of treatment for this highly susceptible population and will further improve their outcome. © 2022 Informa UK Limited, trading as Taylor & Francis Group.

Datos de la publicación

ISSN/ISSNe:
1473-7140, 1744-8328

Expert Review of Anticancer Therapy  TAYLOR & FRANCIS LTD

Tipo:
Review
Páginas:
1183-1196
PubMed:
36191604
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
0,852 SCImago ℠
Cuartil:
Q2 SCImago ℠

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Keywords

  • Adolescent; Cardiotoxicity; Child; Humans; Leukemia, Myeloid, Acute; Typhlitis; amphotericin B lipid complex; caspofungin; fluconazole; granulocyte colony stimulating factor; isavuconazole; itraconazole; micafungin; posaconazole; voriconazole; acute myeloid leukemia; antibiotic prophylaxis; antibiotic therapy; antifungal therapy; bleeding; bone marrow transplantation; cancer chemotherapy; cardiotoxicity; childhood cancer; cryopreservation; echocardiography; febrile neutropenia; fertility preservation; global longitudinal strain; granulocyte transfusion; health care; hematopoietic stem cell transplantation; hemodialysis; human; hydration; hyperkalemia; hyperphosphatemia; hyperuricemia; hypocalcemia; hypokalemia; infection; kidney failure; leukocyte count; leukocytosis; leukostasis; malnutrition; neutropenic enterocolitis; neutrophil count; nutrition; ovary tissue; overall survival; pediatric intensive care unit; platelet count; Pneumocystis pneumonia; promyelocytic leukemia; prophylaxis

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