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Relaxin-2 plasma levels in atrial fibrillation are linked to inflammation and oxidative stress markers

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Aragón-Herrera A.
  • Couselo-Seijas M.
  • Feijóo-Bandín S.
  • Anido-Varela L.
  • Moraña-Fernández S.
  • Martínez-Sande J.L.
  • García-Seara J.
  • Álvarez E.
  • González-Juanatey J.R.
  • Rodríguez-Mañero M.
  • Eiras S.
  • Lago F.

Grupos

Abstract

Relaxin-2 exerts many favourable cardiovascular effects in pathological circumstances such as atrial fibrillation (AF) and heart failure, but the mechanisms underlying its actions are not completely understood. Since inflammation and fibrosis are pivotal processes in the pathogenesis of AF, our aim was to study the relationship between relaxin-2 plasma levels in left atrium (LA) and peripheral vein with molecules implicated in fibrosis, inflammation and oxidative stress in AF patients, and to evaluate the anti-fibrotic ability of relaxin-2 in normal human atrial cardiac fibroblasts (NHCF-A). Peripheral vein relaxin-2 plasma levels were higher than LA relaxin-2 plasma levels in men while, in women, peripheral vein relaxin-2 levels were increased compared to men. AF patients with higher levels of relaxin-2 exhibited a reduction in H2O2 plasma levels and in mRNA levels of alpha-defensin 3 (DEFA3) and IL-6 in leucocytes from LA plasma. Relaxin-2-in-vitro treatment inhibited NHCF-A migration and decreased mRNA and protein levels of the pro-fibrotic molecule transforming growth factor-ß1 (TGF-ß1). Our results support an association between relaxin-2 and molecules involved in fibrosis, inflammation and oxidative stress in AF patients, and reinforce an anti-fibrotic protective role of this hormone in NHCF-A; strengthening the relevance of relaxin-2 in AF physiopathology, diagnosis and treatment. © 2022, The Author(s).

Datos de la publicación

ISSN/ISSNe:
2045-2322, 2045-2322

Scientific Reports  NATURE PORTFOLIO

Tipo:
Article
Páginas:
-
PubMed:
36566255
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
1,005 SCImago ℠
Cuartil:
Q1 SCImago ℠

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Keywords

  • Atrial Fibrillation; Female; Fibrosis; Heart Atria; Humans; Hydrogen Peroxide; Inflammation; Male; Relaxin; RNA, Messenger; Transforming Growth Factor beta1; hydrogen peroxide; messenger RNA; relaxin; transforming growth factor beta1; atrial fibrillation; female; fibrosis; heart atrium; human; inflammation; male; metabolism; pathology

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