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Correlation of Anti-Tissue Transglutaminase Antibodies with the Mucosal Changes and IgA Status of Children with Celiac Disease

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Castillejo G.
  • Sánchez-Valverde F.
  • García-Burriel J.I.
  • Martínez-Ojinaga E.
  • Eizaguirre F.J.
  • Barrio J.
  • Cilleruelo M.
  • Pérez-Solís D.
  • Ochoa-Sangrador C.
  • Vecino-López R.
  • Miranda-Cid M.C.
  • García-Calatayud S.
  • Torres-Peral R.
  • Juste M.
  • Armas H.
  • Barros-García P.
  • Leis R.
  • Solaguren R.
  • Salazar J.C.
  • García-Romero R.
  • Ortigosa L.
  • Peña-Quintana L.
  • Urruzuno P.
  • Codoñer-Franch P.
  • Garcia-Casales Z.
  • Masiques M.L.
  • Galicia-Poblet G.
  • Crehuá-Gaudiza E.
  • Balmaseda E.
  • Rubio-Santiago J.
  • Polanco-Allué I.
  • Román-Riechmann E.

Grupos

Abstract

Objectives: The objective of this study was to assess the association between serological markers and changes of the intestinal mucosa in children with celiac disease (CD). Methods: Clinical data from CD patients under 15 years old were collected from the participating centers in an on-line multicenter nationwide observational Spanish registry called REPAC-2 (2011-2017). Correlation between anti-Tissue transglutaminase antibodies (t-TGA) levels and other variables, including mucosal damage and clinical findings (symptoms, age, and gender), was assessed. Results: A total of 2955 of 4838 patients had t-TGA and a small bowel biopsy (SBB) performed for CD diagnosis. A total of 1931 (66.2%) patients with normal IgA values had a Marsh 3b-c lesion and 1892 (64.9%) had t-TGA Immunoglobulin A (IgA) = 10 times upper limit of normal (ULN). There is a statistically significant association between t-TGA IgA levels and the degree of mucosal damage (P < 0.001), the higher the t-TGA IgA levels the more severe the mucosal damage. Those patients who reported symptoms had more severe mucosal damage (P = 0.001). On the contrary, there was a negative association between age and changes of the intestinal mucosa (P < 0.001). No association was found with gender. Regarding the IgA-deficient patients, 47.4% (18 cases) had t-TGA Immunoglobulin A (IgA) = 10 times ULN and a Marsh 3b-c lesion was observed in 68.4% (26 patients). No statistical relation was found between t-TGA IgG levels and the changes of the intestinal mucosa, neither a relation with age, gender, or symptoms. Conclusions: There is a positive correlation between t-TGA IgA levels and the severity of changes of the intestinal mucosa. Such correlation was not found in IgA-deficient patients who had positive t-TGA IgG serology. The results in this group of patients support the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition recommendations about the need of performing a SBB in IgA-deficient individuals despite high t-TGA IgG levels. © 2022 Lippincott Williams and Wilkins. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0277-2116, 1536-4801

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION  WILEY

Tipo:
Article
Páginas:
743-748
PubMed:
36123770
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
0,919 SCImago ℠
Cuartil:
Q1 SCImago ℠

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Keywords

  • Adolescent; Autoantibodies; Biopsy; Celiac Disease; Child; Humans; Immunoglobulin A; Immunoglobulin G; Transglutaminases; immunoglobulin A; immunoglobulin G; protein glutamine gamma glutamyltransferase antibody; autoantibody; immunoglobulin A; immunoglobulin G; protein glutamine gamma glutamyltransferase; antibody blood level; Article; atrophy; celiac disease; child; controlled study; disease association; disease severity; female; human; human tissue; immunoglobulin A deficiency; immunoglobulin blood level; intestine biopsy; intestine mucosa; major clinical study; male; multicenter study; serology; adolescent; biopsy; celiac disease; clinical trial

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