Impact of parental chromosomal polymorphisms on the incidence of congenital anomalies and perinatal complications in a cohort of newborns conceived after ICSI + PGT-A

Autores de IIS La Fe

• María Cruz Palomino

  Autor

• Antonio Requena Miranda

  Autor

Participantes ajenos a IIS La Fe

• Rodriguez F.

Grupos

• Biomarcadores, Medicina Genómica, Estadística y Análisis masivo de datos en Reproducción humana asistida

• Endocrinología Reproductiva e Infertilidad

Abstract

Background: To assess the association between chromosomal polymorphisms (CPM) with congenital anomalies and perinatal complications in a cohort of newborns from couples undergoing intracytoplasmic sperm injection (ICSI), trophectoderm biopsy, and preimplantation genetic testing for aneuploidy (PGT-A). Methods: A retrospective cohort of singletons conceived after ICSI, trophectoderm biopsy, and PGT-A cycles performed at IVIRMA clinics in Spain over 4 years was involved in the study. Newborns were classified according to the parental karyotype analysis: Group I: non-carriers, Group II: CPM carriers. Couples with chromosomal anomalies and instances when both partners were CPM carriers were excluded from the study. The groups were compared for several perinatal complications. Results: There was a significant decrease in the number of NB with complications in the carrier group compared to the non-carriers (19.7% vs 31.9%, p = 0.0406). There were no statistical differences among the two groups regarding congenital anomalies, preterm birth, alterations in birth length and weight, cranial perimeter, Apgar test score, or sex ratio (p > 0.05). Conclusions: Chromosomal polymorphisms appear to have no adverse effects on congenital anomalies or perinatal complications on newborns from ICSI + PGT-A cycles. © 2022, The Author(s).

Keywords

• Aneuploidy; Female; Fertilization in Vitro; Genetic Testing; Humans; Incidence; Infant, Newborn; Male; Parents; Pregnancy; Premature Birth; Retrospective Studies; Semen; Sperm Injections, Intracytoplasmic; Apgar score; Article; birth length; birth weight; chromosome polymorphism; cohort analysis; congenital malformation; controlled study; embryo culture; embryo transfer; female; head circumference; human; incidence; intracytoplasmic sperm injection; karyotype; major clinical study; male; newborn; parent; perinatal morbidity; preimplantation genetic screening; premature labor; retrospective study; sex ratio; Spain; trophectoderm biopsy; adverse event; aneuploidy; child parent relation; genetic screening; in vitro fertilization; incidence; pregnancy; prematurity; sperm