Can We Improve Our Routine Urological Assessment to Exclude Neurogenic Causes for Lower Urinary Tract Dysfunction? ICI-RS 2024

Autores de IIS La Fe

• Salvador Arlandis Guzmán

  Autor

Participantes ajenos a IIS La Fe

• Drake M.J.
• Averbeck M.A.
• Agrò E.F.
• Hentzen C.
• Mosiello G.
• Panicker J.
• Smith M.
• Webb K.

Grupos

• Urología

Abstract

Aims: After presentation with urinary symptoms, an underlying neurological mechanism sometimes emerges subsequently. Increased awareness may bring earlier diagnosis, improving prognosis and outcomes. Methods: A 2024 International Consultation on Incontinence Research Society think-tank considered the clinical pathway for identification of an undiagnosed neurological or autonomic contribution precipitating urinary symptoms, and the implications for prognosis. Results: Alongside adult-onset neurogenic conditions, potential for missed diagnosis includes congenital and pediatric-acquired neurogenic conditions, which may become symptomatic during a growth spurt due to spinal cord tethering. Detailed assessment is needed, also considering bowel and sexual dysfunction, with timely referral to neurology to reduce preventable progression of disease. In neurological assessment, control of micturition is often poorly characterized compared with other aspects of spinal cord function and the cranial nerves. Screening tools may be used to identify people who have increased likelihood of particular conditions, but currently available tools are either single-system or population specific. In addition to the general pelvic examination, the assessment of sacral reflexes and pelvic sensations can suggest a neurological mechanism, though the sensitivity and specificity of the neuro-urological examination is unknown. Including the results of the neuro-perineal examination in the urodynamic report may improve the interpretation of the results and potentially support a neurological aetiology. Conclusion: Future research should consider the value of neuro-urological examination in diagnosis of occult neurological disease, the development of an occult neurology screening tool/risk scoring based on pelvic organ symptoms, and appropriateness of non-neurologist practitioners requesting neurological investigations such as MRI scanning. Clinical Trial Registration: Does not apply. © 2025 The Author(s). Neurourology and Urodynamics published by Wiley Periodicals LLC.

Keywords

• Humans; Lower Urinary Tract Symptoms; Urinary Bladder, Neurogenic; Urodynamics; adult; awareness; child; cranial nerve; diagnosis; diagnostic test accuracy study; female; growth acceleration; human; lower urinary tract symptom; major clinical study; micturition; missed diagnosis; motor neuron disease; MRI scanner; neural tube defect; neurologic disease; neurologist; nuclear magnetic resonance imaging; patient referral; pelvic examination; pelvic viscera; perineum; review; sensitivity and specificity; sexual dysfunction; spinal cord function; spinal dysraphism; urinary tract disease; urodynamics; neurogenic bladder; pathophysiology; urodynamics