Epidemiology of supplemental oxygen in patients with pulmonary hypertension

Autores de IIS La Fe

• Joaquín Rueda Soriano

  Autor

Participantes ajenos a IIS La Fe

• Hinojosa W.
• Martínez-Meñaca A.
• Sala Llinas E.
• Jiménez Arjona J.
• Aurtenetxe A.
• Barberà J.A.
• Escribano-Subías P.
• Blanco I.
• Álvarez Barredo M.
• Angullo Gómez M.
• Aurtenetxe Pérez A.
• Becerra Muñoz V.M.
• Bedate P.
• Bravo Marqués R.
• Cadenas Menéndez S.
• Callejas Rubio J.L.
• Carmona Segovia A.M.
• Carrillo J.
• Casado Moreno I.
• Castejón Pina N.
• Castro M.
• Chamorro Fernández C.I.
• Cifrián J.M.
• Clavero Sánchez T.
• Crémer Luengos D.
• del Prado Díaz S.
• Dobarro D.
• Domingo Morera J.A.
• Elías Hernández T.
• García Flores P.I.
• García Hernández F.J.
• Gonçalves Dos Santos Carvalho F.
• González Segovia A.
• Guerra Ramos F.J.
• Hermida T.
• Jaimes Diaz S.V.
• Jara Palomares L.
• Lacuey Lecumberri G.
• Lara Padrón A.
• Lázaro Salvador M.
• López-Meseguer M.
• López Reyes R.
• Luna López R.
• Marín González M.
• Márquez Moreno J.M.
• Martínez García F.
• Melendo Viu M.
• Melero Ferrer J.
• Mombiela T.
• Mora Cuesta V.M.
• Naranjo Velasco V.
• Noris Mora M.
• Núñez Ares A.
• Ochoa Parra N.
• Otero Candelera R.
• Otero González I.
• Pastor Pérez F.
• Pérez Peñate G.M.
• Pérez Sagredo J.
• Pérez L.
• Ramírez Martín P.
• Ramón Capilla M.
• Recio Mayoral A.
• Rey Chacón I.
• Ribas Sola J.
• Rodríguez Chiaradía D.A.
• Rodríguez Penas D.
• Sáez Giménez B.
• Safont B.
• Segovia Cubero J.
• Sintes Permanyer H.
• Soto Abánades C.
• Suberviola V.
• Tenes J.A.
• Torrents Vilar A.
• Torres-Castro R.

Grupos

• Grupo de Investigación Clínica y Traslacional en Cardiología

Abstract

Background and Objective: Patients with pulmonary hypertension (PH) may present with hypoxaemia at rest or during daily activities. There is no epidemiological data on the prescription of long-term oxygen therapy (LTOT) in patients with PH. The study sought to analyse the prevalence and incidence of LTOT prescription among patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) in Spain and to determine predictors for this prescription. Methods: A retrospective analysis was performed from the Spanish Registry of Pulmonary Arterial Hypertension (REHAP). Collected data included demographics and anthropometric measurements, functional class (FC), arterial blood gases, pulmonary function tests, haemodynamic measurements, six-minute walking distance (6MWD) and LTOT prescription. In addition, we assessed the prevalence and incidence of LTOT prescription by PH group and subtype and potential predictors for LTOT initiation in the first 5 years after diagnosis. Results: We analysed 4533 patients (69.9% PAH and 30.1% CTEPH), mostly female (64.5%), with a mean age of 53.0 ± 18.3 years. The prevalence of LTOT was 19.3% for all patients. The incidence of LTOT prescriptions decreased from 5.6% to 1.6% between 2010 and 2019, respectively. Predictors for LTOT prescription, excluding those that represent the indication for oxygen therapy were: FC (HR: 1.813), 6MWD (HR: 1.002), mean pulmonary arterial pressure (mPAP) (HR: 1.014), cardiac index (CI) (HR: 1.253), pulmonary vascular resistance (PVR) (HR: 1.023) and diffusing capacity of carbon monoxide (DLCO) (HR: 1.294). Conclusion: The prevalence of LTOT in PAH and CTEPH patients is close to 20%. FC, 6MWD, mPAP, CI, PVR and DLCO were predictors for LTOT prescription. (Figure presented.). © 2024 Asian Pacific Society of Respirology.

Keywords

• Adult; Aged; Female; Humans; Hypertension, Pulmonary; Incidence; Male; Middle Aged; Oxygen Inhalation Therapy; Prevalence; Registries; Retrospective Studies; Spain; oxygen; supplemental oxygen; unclassified drug; adult; anthropometry; arterial gas; Article; cardiac index; chronic thromboembolic pulmonary hypertension; diffusing capacity for carbon monoxide; female; forced expiratory volume; forced vital capacity; hemodynamics; human; long term oxygen therapy; lung artery pressure; lung diffusion capacity; lung function test; lung perfusion; lung vascular resistance; lung wedge pressure; major clinical study; male; New York Heart Association class; oxygen saturation; oxygen therapy; prescription; pulmonary hypertension; retrospective study; six minute walk test; Spain; spirometry; aged; epidemiology; incidence; middle aged; oxygen therapy; pathophysiology; prevalence; procedures; pulmonary hypertension; register; therapy