Fluorescence in situ hybridization for the differential diagnosis between Spitz naevus and spitzoid melanoma.

Autores de IIS La Fe

• Celia Requena Caballero

  Autor

• Luis Alberto Rubio Martinez

  Autor

• Onofre Sanmartin Jimenez

  Autor

• 

  Rafael Botella Estrada

  Autor

• Carlos Guillen Barona

  Autor

Participantes ajenos a IIS La Fe

• Traves V
• Nagore E
• Llombart B
• Serra C
• Fernández-Serra A

Abstract

The differential diagnosis between Spitz naevus and spitzoid melanoma can be extremely difficult, or even impossible. In recent years, many attempts have been made to find specific histopathological or immunohistochemical markers, although none has proved successful. Because the prognosis and treatment of each are very different, it is important to distinguish between these entities. We evaluated the ability of the fluorescence in situ hybridization (FISH) assay-designed to detect the copy number of the RREB1 (6p25), MYB (6q23) and CCND1 (11q13) genes and of centromere 6 (Cep 6)-in order to distinguish between Spitz naevus and spitzoid melanoma.