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  3. Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Nicolas A.
  • Sherva R.
  • Grenier-Boley B.
  • Kim Y.
  • Kikuchi M.
  • Timsina J.
  • de Rojas I.
  • Dalmasso M.C.
  • Zhou X.
  • Le Guen Y.
  • Arboleda-Bustos C.E.
  • Camargos Bicalho M.A.
  • Guerchet M.
  • van der Lee S.
  • Goss M.
  • Castillo A.
  • Bellenguez C.
  • Küçükali F.
  • Satizabal C.L.
  • Fongang B.
  • Yang Q.
  • Peters O.
  • Schneider A.
  • Dichgans M.
  • Rujescu D.
  • Scherbaum N.
  • Deckert J.
  • Riedel-Heller S.
  • Hausner L.
  • Molina-Porcel L.
  • Düzel E.
  • Grimmer T.
  • Wiltfang J.
  • Heilmann-Heimbach S.
  • Moebus S.
  • Tegos T.
  • Scarmeas N.
  • Dols-Icardo O.
  • Moreno F.
  • Pérez-Tur J.
  • Bullido M.J.
  • Pastor P.
  • Sánchez-Valle R.
  • Álvarez V.
  • Cao H.
  • Ip N.Y.
  • Fu A.K.Y.
  • Ip F.C.F.
  • Olivar N.
  • Muchnik C.
  • Cuesta C.
  • Campanelli L.
  • Solis P.
  • Politis D.G.
  • Kochen S.
  • Brusco L.I.
  • Boada M.
  • García-González P.
  • Puerta R.
  • Mir P.
  • Real L.M.
  • Piñol-Ripoll G.
  • García-Alberca J.M.
  • Rodriguez-Rodriguez E.
  • Soininen H.
  • Heikkinen S.
  • de Mendonça A.
  • Mehrabian S.
  • Traykov L.
  • Hort J.
  • Vyhnalek M.
  • Rasmussen K.L.
  • Thomassen J.Q.
  • Pijnenburg Y.A.L.
  • Holstege H.
  • van Swieten J.C.
  • Seelaar H.
  • Claassen J.A.H.R.
  • Jansen W.J.
  • Ramakers I.
  • Verhey F.
  • van der Lugt A.
  • Scheltens P.
  • Ortega-Rojas J.
  • Concha Mera A.G.
  • Mahecha M.F.
  • Pardo R.
  • Arboleda G.
  • Bahrami S.
  • Fominykh V.
  • Selbæk G.
  • Graff C.
  • Papenberg G.
  • Giedraitis V.
  • Boland A.
  • Deleuze J.-F.
  • de Marco L.A.
  • de Moraes E.N.
  • de Mattos Viana B.
  • Túlio Gualberto Cintra M.
  • Juarez-Cedillo T.
  • Griswold A.J.
  • Forund T.
  • Haines J.
  • Farrer L.
  • DeStefano A.
  • Wijsman E.
  • Mayeux R.
  • Pericak-Vance M.
  • Kunkle B.
  • Goate A.
  • Schellenberg G.D.
  • Vardarajan B.
  • Wang L.-S.
  • Leung Y.Y.
  • Dalgard C.L.
  • Nicolas G.
  • Wallon D.
  • Dufouil C.
  • Pasquier F.
  • Hanon O.
  • Debette S.
  • Grünblatt E.
  • Popp J.
  • Angel B.
  • Gloger S.
  • Chacon M.V.
  • Aranguiz R.
  • Orellana P.
  • Slachevsky A.
  • Gonzalez-Billault C.
  • Albala C.
  • Fuentes P.
  • Sachdev P.
  • Mather K.A.
  • Hauger R.L.
  • Merritt V.
  • Panizzon M.
  • Zhang R.
  • Gaziano J.M.
  • Ghidoni R.
  • Galimberti D.
  • Arosio B.
  • Mecocci P.
  • Solfrizzi V.
  • Parnetti L.
  • Squassina A.
  • Tremolizzo L.
  • Borroni B.
  • Nacmias B.
  • Caffarra P.
  • Seripa D.
  • Rainero I.
  • Daniele A.
  • Piras F.
  • Zulaica M.
  • Yannakoulia M.
  • Woods B.
  • Windle G.
  • Weinhold L.
  • Wagner M.
  • Vogelgsang J.
  • Vidal J.-S.
  • Vandenberghe R.
  • Van Dongen J.
  • Van Broeckhoven C.
  • Valero S.
  • Ulstein I.
  • Ullgren A.
  • Uitterlinden A.
  • Tybjærg-Hansen A.
  • Thomas T.
  • Thalamuthu A.
  • Tesí N.
  • Tárraga L.
  • Tartan J.P.
  • Stordal E.
  • Spottke A.
  • Sotolongo-Grau O.
  • Sorbi S.
  • Solomon A.
  • Skrobot O.
  • Shadrin A.A.
  • Schott J.M.
  • Schmid M.
  • Scherer M.
  • Scarpini E.
  • Scamosci M.
  • Sando S.B.
  • Sánchez-Juan P.
  • Sanchez-Garcia F.
  • Bernal Sánchez-Arjona M.
  • Sanabria Á.
  • Saltvedt I.
  • Sakka P.
  • Sáez M.E.
  • Rubino E.
  • Royo J.L.
  • Rosende-Roca M.
  • Allende I.R.
  • Rongve A.
  • Roberto N.
  • Riederer P.
  • Reinders M.J.T.
  • Rábano A.
  • Quintela I.
  • Quenez O.
  • Priller J.
  • Posthuma D.
  • Polak T.
  • Pisanu C.
  • Pineda J.A.
  • Pericard P.
  • Pérez-Cordón A.
  • Padovani A.
  • Ortega G.
  • Orsini M.
  • Orellana A.
  • Olaso R.
  • Nordestgaard B.G.
  • Ngandu T.
  • Möthen M.M.
  • Morgan K.
  • Montrreal L.
  • Mol M.
  • Menéndez-González M.
  • Mendoza S.
  • Meggy A.
  • Medina M.
  • Mead S.
  • Martínez Rodríguez C.
  • Montes A.M.
  • Marshall R.
  • Marquié M.
  • Spallazzi M.
  • Mangialasche F.
  • Maier W.
  • MacLeod C.A.
  • Macías J.
  • Luckcuck L.
  • Löwemark M.
  • Love S.
  • López-de Munain A.
  • Lleó A.
  • Lerch O.
  • Lehtisalo J.
  • Lauria A.
  • Laukka E.J.
  • Lage C.
  • Kosmidis M.H.
  • Kornhuber J.
  • Koivisto A.
  • Kivipelto M.
  • Ståhlbom A.K.
  • Kilander L.
  • Johansson C.
  • Biessels G.J.
  • Hulsman M.
  • Huerto Vilas R.
  • Holmes C.
  • Hoffmann P.
  • Herrmann M.J.
  • Hernández I.
  • Heneka M.T.
  • Helisalmi S.
  • Harwood J.
  • Hartmann A.M.
  • Hardy J.
  • Hampel H.
  • Hadjigeorgiou G.
  • Haapasalo A.
  • Guetta-Baranes T.
  • Green E.
  • Grande G.
  • González-Pérez A.
  • Goldhardt O.
  • Giorgio G.
  • Giegling I.
  • Garcia-Ribas G.
  • Garcia-Madrona S.
  • Froelich L.
  • Frank-García A.
  • Franco-Macías E.
  • Fox N.C.
  • Fostinelli S.
  • Foroud T.M.
  • Fortea J.
  • Fließbach K.
  • Fladby T.
  • Fischer P.
  • Fin B.
  • Ferri E.
  • Ferreira C.B.
  • Fernández-Fuertes M.
  • Fenoglio C.
  • Farotti L.
  • Nielsen S.F.
  • Fabrizio T.
  • Ewers M.
  • Espinosa A.
  • Engelborghs S.
  • Duron E.
  • Djurovic S.
  • Rossi P.D.
  • Diez-Fairen M.
  • Diehl-Schmid J.
  • Denning N.
  • del Ser T.
  • de Deyn P.P.
  • Dardiotis E.
  • Daian D.
  • Custodero C.
  • Giuffrè G.M.
  • Corma-Gómez A.
  • Conti E.
  • Clark C.
  • Clarimon J.
  • Ciccone S.
  • Chillotti C.
  • Charbonnier C.
  • Cervera-Carles L.
  • Cecchetti R.
  • Carracedo Á.
  • Chene G.
  • Calero M.
  • Burholt V.
  • Bûrger K.
  • Buiza-Rueda D.
  • Brookes K.J.
  • Brodaty H.
  • Bresner C.
  • Bråthen G.
  • Bossù P.
  • Boschi S.
  • Blesa R.
  • Bizarro A.
  • Binetti G.
  • Bessi V.
  • Besse C.
  • Berr C.
  • Bellini S.
  • Pastor A.B.
  • Banaj N.
  • Bailly H.
  • Athanasiu L.
  • Arias Pastor A.
  • Archetti S.
  • Arcaro M.
  • Appollonio I.
  • Anthoula T.
  • Armstrong N.J.
  • Alvarez I.
  • Alegret M.
  • Alcolea D.
  • Alarcón-Martín E.
  • Abdelnour C.
  • Garcia-Gonzalez P.
  • Aarsland D.
  • Kleineidam L.
  • Holmans P.A.
  • Amin N.
  • Moreno-Grau S.
  • Leonard H.L.
  • Yokoyama J.S.
  • Nalls M.A.
  • Miyashita A.
  • Hara N.
  • Ozaki K.
  • Niida S.
  • Williams J.
  • Masullo C.
  • Amouyel P.
  • Preux P.-M.
  • Mbelesso P.
  • Bandzouzi B.
  • Saykin A.
  • Jessen F.
  • Kehoe P.G.
  • Van Duijn C.
  • Ben Salem N.
  • Frikke-Schmidt R.
  • Cherni L.
  • Greicius M.D.
  • Tsolaki M.
  • Romano Silva M.A.
  • Porter T.
  • Laws S.M.
  • Sleegers K.
  • Ingelsson M.
  • Dartigues J.-F.
  • Seshadri S.
  • Rossi G.
  • Morelli L.
  • Hiltunen M.
  • Sims R.
  • van der Flier W.
  • Andreassen O.A.
  • Arboleda H.
  • Cruchaga C.
  • Escott-Price V.
  • Ruiz A.
  • Lee K.H.
  • Ikeuchi T.
  • Ramirez A.
  • Gim J.
  • Logue M.
  • Lambert J.-C.

Grupos

Abstract

A polygenic score (PGS) for Alzheimer’s disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD. © The Author(s) 2025.

Datos de la publicación

ISSN/ISSNe:
1061-4036, 1546-1718

NATURE GENETICS  NATURE PORTFOLIO

Tipo:
Article
Páginas:
1598-1610
PubMed:
40533518
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
16,517 SCImago ℠
Cuartil:
Q1 SCImago ℠

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Keywords

  • Aged; Alzheimer Disease; Apolipoproteins E; Biomarkers; Europe; Female; Genetic Predisposition to Disease; Genetic Risk Score; Genome-Wide Association Study; Humans; Male; Multifactorial Inheritance; Polymorphism, Single Nucleotide; Risk Factors; White People; amyloid beta protein[1-42]; apolipoprotein E; tau protein; apolipoprotein E; biological marker; adult; Africa; African American; allele; Alzheimer disease; Article; Asia; Belgium; cerebrospinal fluid level; Chinese; chromosome; cognitive defect; cohort analysis; East Asian; endophenotype; European; European American; Finland; France; gene frequency; gene linkage disequilibrium; gene locus; genetic association; genetic risk score; genetics; genome-wide association study; genotype; genotyping; Germany; human; Korean (people); major clinical study; Netherlands; single nucleotide polymorphism; South and Central America; Spain; Sweden; whole genome sequencing; aged; Alzheimer disease; Caucasian; cerebrospinal fluid; epidemiology; Euro

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