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  3. Postoperative serum VEGF concentration and recurrence after curative colon cancer surgery: findings from a multicenter prospective cohort

Postoperative serum VEGF concentration and recurrence after curative colon cancer surgery: findings from a multicenter prospective cohort

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Téllez C.
  • Labró-Ciurans M.
  • de la Serna S.
  • Hernando R.
  • Caro A.
  • Parés D.
  • Mayol X.
  • Vizoso A.
  • Durán X.
  • Morató O.
  • Pera M.
  • Pascual M.

Grupos

Abstract

Background: Angiogenesis is essential for tumor progression, with vascular endothelial growth factor (VEGF) as a key regulator. A prior single-center study identified VEGF >370 ?pg/mL on postoperative day 4 (POD4) as a predictor of recurrence in colon cancer (CC). Methods: We conducted a prospective study including 255 patients undergoing curative-intent CC surgery across seven Spanish institutions (NTC04851054). Serum VEGF was measured via ELISA on POD4. Results: After a median follow-up of 34 months, recurrence occurred in 15.7 ?% of patients. The previously proposed VEGF cutoff was not validated. No significant differences in VEGF were observed between patients with and without recurrence. However, higher VEGF levels were associated with open surgery (p ?= ?0.013) and postoperative complications (p ?< ?0.001), with a trend in anastomotic leakage (p ?= ?0.062). Conclusions: VEGF was not predictive of recurrence in this setting but remains a relevant marker of perioperative angiogenic activity, warranting further investigation. © 2025 Elsevier Inc.

Datos de la publicación

ISSN/ISSNe:
0002-9610, 1879-1883

AMERICAN JOURNAL OF SURGERY  EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC

Tipo:
Article
Páginas:
-
PubMed:
40957284
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
0,870 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 1

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Keywords

  • Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Colectomy; Colonic Neoplasms; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Postoperative Complications; Postoperative Period; Prospective Studies; Vascular Endothelial Growth Factor A; carcinoembryonic antigen; vasculotropin; tumor marker; vasculotropin A; VEGFA protein, human; adjuvant chemotherapy; adult; aged; anastomosis; anastomosis leakage; angiogenesis; Article; blood sampling; cancer chemotherapy; cancer recurrence; cancer staging; cancer surgery; cohort analysis; colectomy; colon cancer; computer assisted tomography; disease free survival; enzyme linked immunosorbent assay; female; follow up; histology; histopathology; human; human tissue; ileus; laparoscopy; length of stay; lymph vessel metastasis; major clinical study; male; mesentery; morbidity; mortality; multicenter study; open surgery; overall survival; perineural invasion; postoperative complication; postoperative period; propensity

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