HIV Infection Is Associated With a Less Aggressive Phenotype of Inflammatory Bowel Disease: A Multicenter Study of the ENEIDA Registry.

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Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Calafat M
  • Suria C
  • Mesonero F
  • de Francisco R
  • Yagüe Caballero C
  • de la Peña L
  • Hernández-Camba A
  • Marcé A
  • Gallego B
  • Martín-Vicente N
  • Rivero M
  • Guerra I
  • Carrillo-Palau M
  • Madero L
  • Burgueño B
  • Monfort D
  • Torres G
  • Teller M
  • Ferrer Rosique JÁ
  • Vega Villaamil P
  • Roig C
  • Ponferrada-Diaz A
  • Betoré Glaría E
  • Zabana Y
  • Gisbert JP
  • Busquets D
  • Alcaide N
  • Camps B
  • Legido J
  • González-Vivo M
  • Bosca-Watts MM
  • Pérez-Martínez I
  • Casas Deza D
  • Guardiola J
  • Arranz Hernández L
  • Navarro M
  • Gargallo-Puyuelo CJ
  • Cañete F
  • Mañosa M
  • Domènech E
  • ENEIDA Registry of GETECCU

Grupos

Abstract

INTRODUCTION: The coexistence of HIV infection and inflammatory bowel disease (IBD) is uncommon. Data on the impact of HIV on IBD course and its management are scarce. The aim of this study was to describe the IBD phenotype, therapeutic requirements, and prevalence of opportunistic infections (OIs) in IBD patients with a coexistent HIV infection. METHODS: Case-control, retrospective study includes all HIV-positive patients diagnosed with IBD in the Nationwide study on genetic and environmental determinants of inflammatory bowel disease registry. Patients with positive HIV serology (HIV-IBD) were compared with controls (HIV seronegative), matched 1:3 by year of IBD diagnosis, age, sex, and type of IBD. RESULTS: A total of 364 patients (91 HIV-IBD and 273 IBD controls) were included. In the whole cohort, 58% had ulcerative colitis, 35% had Crohn's disease (CD), and 7% were IBD unclassified. The HIV-IBD group presented a significantly higher proportion of proctitis in ulcerative colitis and colonic location in CD but fewer extraintestinal manifestations than controls. Regarding treatments, nonbiological therapies (37.4% vs 57.9%; P = 0.001) and biologicals (26.4% vs 42.1%; P = 0.007), were used less frequently among patients in the HIV-IBD group. Conversely, patients with HIV-IBD developed more OI than controls, regardless of nonbiological therapy use. In the multivariate analysis, HIV infection (odds ratio 4.765, 95% confidence interval (CI) 2.48-9.14; P < 0.001) and having =1 comorbidity (OR 2.445, 95% CI 1.23-4.85; P = 0.010) were risk factors for developing OI, while CD was protective (OR 0.372, 95% CI 0.18-0.78; P = 0.009). DISCUSSION: HIV infection seems to be associated with a less aggressive phenotype of IBD and a lesser use of nonbiological therapies and biologicals but entails a greater risk of developing OI.

Copyright © 2024 by The American College of Gastroenterology.

Datos de la publicación

ISSN/ISSNe:
0002-9270, 1572-0241

AMERICAN JOURNAL OF GASTROENTEROLOGY  LIPPINCOTT WILLIAMS & WILKINS

Tipo:
Article
Páginas:
431-439
PubMed:
39888687
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
2,683 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 5

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Keywords

  • Adult; Biological Products; Case-Control Studies; Colitis, Ulcerative; Crohn Disease; Female; HIV Infections; Humans; Inflammatory Bowel Diseases; Italy; Male; Middle Aged; Phenotype; Prevalence; Registries; Retrospective Studies; cyclosporine; Janus kinase inhibitor; mercaptopurine; methotrexate; ustekinumab; biological product; adult; Article; case control study; CD4 lymphocyte count; CD8 lymphocyte count; controlled study; Crohn disease; human; Human immunodeficiency virus; Human immunodeficiency virus infection; immunosuppressive treatment; inflammatory bowel disease; logistic regression analysis; major clinical study; male; multicenter study; multivariate analysis; opportunistic infection; phenotype; prevalence; retrospective study; survival analysis; ulcerative colitis; virus load; clinical trial; complication; Crohn disease; epidemiology; female; Human immunodeficiency virus infection; inflammatory bowel disease; Italy; middle aged; register; ulcerative colitis

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