Portal de investigación
Role of spot urinary sodium in outpatients with heart failure
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Lorenzo, M
- de la Espriella, R
- Miñana, G
- Núñez, G
- Carratalá, A
- Rodríguez, E
- Santas, E
- Valls, N
- Villar, S
- Bayes-Genis, A
- Sanchis, J
- Núñez, J
Grupos
Abstract
Introduction and objectives: Spot determination of urinary sodium (UNa+) has emerged as a useful tool for monitoring diuretic response in patients with acute heart failure (AHF). However, the evidence in outpatients is scarce. We aimed to examine the relationship between spot UNa+ levels and the risk of mortality and worsening heart failure (WHF) events in individuals with chronic HF. Methods: This observational and ambispective study included 1145 outpatients with chronic HF followed in a single center specialized HF clinic. UNa+ assessment was carried out 1-5 days before each visit. The endpoints of the study were the association between UNa+ and risk of a) long-term death and b) AHF-hospitalization and total WHF events (including AHF-hospitalization, emergency department visits or parenteral loop-diuretic administration in HF clinic), assessed by multivariate Cox and negative binomial regressions. Results: The mean +/- standard deviation of age was 73 +/- 11 years, 670 (58.5%) were men, 902 (78.8%) were on stable NYHA class II, and 595 (52%) had LFEF >= 50%. The median (interquartile range) UNa+ was 72 (51-94) mmol/L. Over a median follow-up of 2.63 (1.70-3.36) years, there were 293 (25.6%) deaths and 382 WHF events (244 AHF-admissions) in 233 (20.3%) patients. After multivariate adjustment, baseline UNa+ was inverse and linearly associated with the risk of total WHF (IRR, 1.07; 95%CI, 1.02-1.12; P = .007) and AHFadmissions (IRR, 1.08; 95%CI, 1.02-1.14; P = .012) and borderline associated with all-cause mortality (HR, 1.04; 95%CI, 0.99-1.09; P = .068). Conclusions: In outpatients with chronic HF, lower UNa+ was associated with a higher risk of recurrent WHF events.(c) 2024 Sociedad Espanola de Cardiolog & imath;<acute accent>a. Published by Elsevier Espana, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Datos de la publicación
- ISSN/ISSNe:
- 1885-5857, 1885-5857
- Tipo:
- Article
- Páginas:
- 185-195
- PubMed:
- 39038750
- Factor de Impacto:
- 0,385 SCImago ℠
- Cuartil:
- Q3 SCImago ℠
REVISTA ESPANOLA DE CARDIOLOGIA EDICIONES DOYMA S A
Citas Recibidas en Web of Science: 5
Documentos
- No hay documentos
Filiaciones
Keywords
- Chronic heart failure; Outpatients; Urinary sodium; Worsening heart failure
Cita
Lorenzo M,de la Espriella R,Miñana G,Núñez G,Carratalá A,Rodríguez E,Santas E,Valls N,Villar S,DONOSO V,Bayes A,Sanchis J,Núñez J. Role of spot urinary sodium in outpatients with heart failure. Rev Esp Cardiol (Engl Ed). 2025. 78. (3):p. 185-195. IF:4,200. (2).