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Characterization and economic burden of KRASG12C-mutant lung cancer in real-world Spanish practice: a retrospective observational study (SILK study)

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Reguart, N
  • Sampietro-Colom, L
  • Aguiló, M
  • Arriola, E
  • Sánchez, J
  • Fernández-Barceló, C
  • Abbas, I
  • López, C
  • Botella, X
  • Cots, F
  • Teixido, C
  • Martínez, D
  • Borràs, E
  • Masfarré, L
  • Cuesta, CS
  • Lopez, MEG
  • Planellas, L
  • Lloansí, A

Grupos

Abstract

Introduction: Real-world evidence on the direct healthcare costs of patients with KRASG12C-mutant non-small-cell lung cancer (NSCLC) is limited. Material and Methods: Multicenter, observational, retrospective study in patients newly diagnosed with advanced-stage NSCLC harboring the KRASG12C mutation within real-world clinical practice in Spain. Patient characteristics, treatment patterns, outcomes, and direct healthcare costs were collected from medical records and administrative databases between January 1, 2016, and March 9, 2022. Results: 127 patients were included in the study, with global and disease-related economic data available for 125 and 104 patients, respectively. Most patients (97.6%) were current or former smokers. The most prevalent co-mutations or genetic alterations at baseline involved TP53 (38.2%), ATM (20.0%), and STK11 (15.4%) genes. 94 patients (74.0%) received systemic therapy. Chemotherapy was the most common first-line (63.8%) and immunotherapy the most common second-line therapy (64.6%). Median progression-free survival (95% CI) for the first, second and third treatment lines was 4.6 (2.8-7.8), 3.8 (1.5-8.2), and 2.2 (0.1-9.9) months, respectively. Median overall survival (95% CI) was 7.7 (4.9-11.0), 9.0 (3.0-14.3), and 8.9 (0.1-19.7) months, respectively. Total global cost over the study period amounted to <euro>5,706,820 (<euro>46,023 per patient), with pharmacological costs totaling <euro>2,353,299 (<euro>18,978 per patient). Disease-related costs were <euro>4,219,410 (<euro>40,965 per patient), with disease-related pharmacological costs of <euro>2,157,627 (<euro>20,948 per patient). Conclusion: These real-world data highlight the limited outcomes for most NSCLC patients with KRASG12C mutations, underscoring the significant clinical and economic burden associated with their care. The evaluation of the impact of novel and effective targeted therapies is therefore warranted.

Copyright © 2025. Published by Elsevier B.V.

Datos de la publicación

ISSN/ISSNe:
0169-5002, 1872-8332

LUNG CANCER  ELSEVIER IRELAND LTD

Tipo:
Article
Páginas:
108677-108677
PubMed:
40712287
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
1,399 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 1

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Keywords

  • Advanced non-small-cell lung cancer; KRASG12C mutation; Retrospective; Burden; Survival; Cost-analysis

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