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Metabolomic Biomarkers of Pulmonary Fibrosis in COVID-19 Patients One Year After Hospital Discharge

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Tarraso, J
  • Mulet, A
  • Presa-Fernandez, L
  • Fernandez-Fabrellas, E
  • Portal, JAR
  • Ros, JA
  • Lozano-Vicente, D
  • Bernardos, A
  • Signes-Costa, J

Grupos

Abstract

Coronavirus disease 2019 (COVID-19) global pandemic has affected more than 600 million people up to date. The symptomatology and severity of COVID-19 are very broad, and there are still concerns about the long-term sequelae that it can have on discharged patients. The development of pulmonary fibrotic sequelae after this infection is especially worrying. Our aim was to determine if there was a metabolomic signature that could predict the development of pulmonary fibrotic sequelae. It is a multicenter prospective observation subcohort based on the COVID-FIBROTIC study. A metabolomic analysis was performed by nuclear magnetic resonance (NMR) on serum samples from patients admitted with bilateral COVID-19 pneumonia collected 2 months after hospital discharge. One year after admission, clinical, functional and radiological data were collected from these same patients. Finally, 109 patients (mean age 57.68 [DS14.03], 65.13% male) were available. Fibrotic sequelae 1 year after COVID-19 disease were found in 33% of them. Based on the NMR analysis of the serum samples, it was possible to distinguish with 80.82% of sensitivity, 72.22% of specificity and 0.83 of an area under the curve (AUC) value which patients would have radiological signs of pulmonary fibrotic pattern 1 year after sample collection. According to the metabolites participating in the discriminative model and the univariate statistics, glucose, valine, and fatty acids (& boxH;CH-CH2-CH & boxH;) were suggested as potential biomarkers of the development of pulmonary fibrotic sequelae after COVID-19.

© 2025 Wiley Periodicals LLC.

Datos de la publicación

ISSN/ISSNe:
0146-6615, 1096-9071

JOURNAL OF MEDICAL VIROLOGY  WILEY

Tipo:
Article
Páginas:
-
PubMed:
40088077
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
2,656 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 2

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Keywords

  • H-1-NMR spectroscopy; biomarkers; COVID-19; metabolomics; pulmonary fibrosis

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