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  3. Risk of preeclampsia and other pregnancy complications in frozen single euploid embryo transfers after natural versus artificial endometrial preparation: A truncated randomized controlled trial

Risk of preeclampsia and other pregnancy complications in frozen single euploid embryo transfers after natural versus artificial endometrial preparation: A truncated randomized controlled trial

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Bellver, J
  • Del Arco, A
  • Pellicer, A
  • Caracena, L
  • Serra, V
  • Castillón, G
  • Fernández, G
  • Barrio, A
  • Ortega, I
  • Fernández, I
  • Torres, M
  • Ballesteros, A
  • Muñoz, E
  • Marqueta, J
  • Ferrando, M
  • Grañeras, A
  • Bartha, JL

Grupos

Abstract

Introduction: To determine for the first time the incidence of preeclampsia and other pregnancy complications according to the mode of endometrial preparation for frozen embryo transfer (FET) in a randomized fashion. Methods: Women about to undergo FET of a single euploid blastocyst were randomly assigned to a modified natural cycle (MNC) or an artificial cycle (AC). Inclusion criteria were as follows: Caucasian; non-obese; 18-43 years of age; nulliparity; regular menstrual cycles; and autologous oocytes. Exclusion criteria were as follows: uterine alterations; moderate-heavy smokers; gamete donation; and chronic diseases. A pilot sub-study of firsttrimester markers of preeclampsia was performed in 60 of the patients. Results: Of the 1260 patients estimated, 591 met the inclusion criteria and were willing to participate; of these, 306 and 285 were randomly assigned to a MNC or AC, respectively. After exclusion, 242 and 227 patients finally underwent a MNC or AC, resulting in 131 and 103 clinical pregnancies, 121 and 92 live births, and 91 and 70 questionnaires obtained concerning pregnancy complications, respectively. The incidence of preeclampsia was double in the AC group (10.00 % versus 4.39 %), though not significantly different. In the AC group, the prevalence of first trimester bleeding was significantly higher (42.85 % versus 15.38 %), and there was a significant reduction in live birth rates (40.53 % versus 50.00 %) in the per protocol analysis. No differences in early markers of preeclampsia were detected between the two groups.

Copyright © 2025 Elsevier Ltd. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0143-4004, 1532-3102

PLACENTA  W B SAUNDERS CO LTD

Tipo:
Article
Páginas:
1-7
PubMed:
40023009
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
0,840 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 12

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Keywords

  • Endometrial preparation; First-trimester bleeding; Frozen embryo transfers; Live birth; Preeclampsia; Randomized controlled trial

Proyectos y Estudios Clínicos

Impacto de la presencia o ausencia de cuerpo lúteo en la incidencia de preeclampsia tras la transferencia de embriones congelados

Investigador Principal: JOSÉ BELLVER PRADAS

PI20/00282 . INSTITUTO DE SALUD CARLOS III . 2021

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