Epidemiological characteristics of antimicrobial use in Primary Care in Spain: a nationwide study

Autores de IIS La Fe

• Héctor Sánchez Herrero

  Autor

• Álvaro José Solaz García

  Autor

• Alejandro Pinilla González

  Autor

• María Cernada Badía

  Autor

Participantes ajenos a IIS La Fe

• Martínez-Sánchez, EV
• Santágueda-Balader, P

Grupos

• Perinatología

Abstract

Introduction: This study aims to describe antimicrobial use in primary care across Spain by analyzing the prescriptions dispensed in pharmacies. Antimicrobials were categorized into therapeutic action groups based on the ATC-2 classification: antibacterials (J01), antimycotics (J02), antimycobacterials (J04), and antivirals (J05). Additionally, the study explores epidemiological patterns of use. Methods: A retrospective observational study was conducted using data from the Primary Care Clinical Database (BDCAP) for 2023. The analysis focused on defined daily doses (DDD) per 1,000 persons/day (DHD), and the number of individuals with at least one antimicrobial prescription in primary care. Data were stratified by age, sex, municipality size, income level, country of birth, and employment status. Changes in prescriptions percentages in 2017 and 2023, as well as variations by age group Results: An overall upward temporal trend in the antimicrobial DHD was observed from 2017 to 2023 (increase of 20.2%), with a decrease in usage during 2020 and 2021. Women exhibited higher DHD for antibacterials, antimycotics, and antivirals, whereas men demonstrated higher DHD for antimycobacterials. Notably, antimycobacterial agents had higher DHD in municipalities with populations exceeding 100,000 inhabitants and among foreign-born individuals. Out of 46,762,487 people assigned to primary care, 14,056,450 received prescribed antimicrobials in 2023. interventions to encourage the rational use of antimicrobials, particularly in high-use groups.

© 2025 Sociedad Española de Quimioterapia. Este es un artículo open access bajo la licencia CC BY-NC 4.0.

Keywords

• Antimicrobials; Antibiotics; Antibacterials. Antifungals; Antimycotics; Antimycobacterials; Antivirals; Primary care; Antimicrobial resistance; Antimicrobial stewardship