Portal de investigación
Controversy and Consensus on Indications for Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Agarwal, A
- Farkouh, A
- Saleh, R
- Hamoda, TAAAM
- Harraz, AM
- Kavoussi, P
- Arafa, M
- Salvio, G
- Rambhatla, A
- Toprak, T
- Gül, M
- Phuoc, NHV
- Boitrelle, F
- Birowo, P
- Abou Ghayda, R
- Cannarella, R
- Kuroda, S
- Durairajanayagam, D
- Zini, A
- Wyns, C
- Sarikaya, S
- Tremellen, K
- Mostafa, T
- Sokolakis, I
- Evenson, DP
- Henkel, R
- Zohdy, W
- Chung, E
- Ziouziou, I
- Falcone, M
- Russo, GI
- Al-Hashimi, M
- Calogero, AE
- Ko, E
- Colpi, G
- Lewis, S
- Serefoglu, EC
- Bahar, F
- Martinez, M
- Nguyen, Q
- Ambar, RF
- Bakircioglu, ME
- Kandil, H
- Mogharabian, N
- Sabbaghian, M
- Taniguchi, H
- Tsujimura, A
- Sajadi, H
- Ibrahim, W
- Atmoko, W
- Vogiatzi, P
- Gunes, S
- Gilani, MAS
- Roychoudhury, S
- Güngör, ND
- Hakim, L
- Adriansjah, R
- Kothari, P
- Jindal, S
- Amar, E
- Park, HJ
- Long, TQT
- Homa, S
- Karthikeyan, VS
- Zilaitiene, B
- Rosas, IM
- Marino, A
- Pescatori, E
- Ozer, C
- Akhavizadegan, H
- Busetto, GM
- Adamyan, A
- Al-Marhoon, M
- Elbardisi, H
- Dolati, P
- Darbandi, M
- Darbandi, S
- Balercia, G
- Pinggera, GM
- Micic, S
- Ho, CCK
- Moussa, M
- Preto, M
- Zenoaga-Barbarosie, C
- Smith, RP
- Kosgi, R
- de la Rosette, J
- El-Sakka, AI
- Abumelha, SM
- Mierzwa, TC
- Ong, TA
- Banihani, SA
- Bowa, K
- Fukuhara, S
- Boeri, L
- Danacioglu, YO
- Gokalp, F
- Selim, OM
- Cho, CL
- Tadros, NN
- Ugur, MR
- Ozkent, MS
- Chiu, P
- Kalkanli, A
- Khalafalla, K
- Vishwakarma, RB
- Finocchi, F
- Andreadakis, S
- Giulioni, C
- Çeker, G
- Ceyhan, E
- Malhotra, V
- Yilmaz, M
- Timpano, M
- Barrett, TL
- Kim, SHK
- Ahn, ST
- Giacone, F
- Palani, A
- Duarsa, GWK
- Kadioglu, A
- Gadda, F
- Zylbersztejn, DS
- Aydos, K
- Kulaksiz, D
- Gupte, D
- Calik, G
- Karna, KK
- Drakopoulos, P
- Baser, A
- Kumar, V
- Molina, JMC
- Rajmil, O
- Ferreira, RH
- Leonardi, S
- Avoyan, A
- Sogutdelen, E
- Franco, G
- Ramsay, J
- Ramirez, L
- Shah, R
- Global Andrology Forum
Grupos
Abstract
Purpose: Sperm DNA fragmentation (SDF) testing was recently added to the sixth edition of the World Health Organization laboratory manual for the examination and processing of human semen. Many conditions and risk factors have been associated with elevated SDF; therefore, it is important to identify the population of infertile men who might benefit from this test. The purpose of this study was to investigate global practices related to indications for SDF testing, compare the relevant professional society guideline recommendations, and provide expert recommendations. Materials and Methods: Clinicians managing male infertility were invited to take part in a global online survey on SDF clinical practices. This was conducted following the CHERRIES checklist criteria. The responses were compared to professional society guideline recommendations related to SDF and the appropriate available evidence. Expert recommendations on indications for SDF testing were then formulated, and the Delphi method was used to reach consensus. Results: The survey was completed by 436 experts from 55 countries. Almost 75% of respondents test for SDF in all or some men with unexplained or idiopathic infertility, 39% order it routinely in the work-up of recurrent pregnancy loss (RPL), and 62.2% investigate SDF in smokers. While 47% of reproductive urologists test SDF to support the decision for varicocele repair surgery when conventional semen parameters are normal, significantly fewer general urologists (23%; p=0.008) do the same. Nearly 70% would assess SDF before assisted reproductive technologies (ART), either always or for certain conditions. Recurrent ART failure is a common indication for SDF testing. Very few society recommendations were found regarding SDF testing. Conclusions: This article presents the largest global survey on the indications for SDF testing in infertile men, and demonstrates diverse practices. Furthermore, it highlights the paucity of professional society guideline recommendations. Expert recommendations are proposed to help guide clinicians.
Datos de la publicación
- ISSN/ISSNe:
- 2287-4208, 2287-4690
- Tipo:
- Article
- Páginas:
- 575-602
- DOI:
- 10.5534/wjmh.220282
- PubMed:
- 37118960
- Factor de Impacto:
- 0,788 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
World Journal of Mens Health KOREAN SOC SEXUAL MEDICINE & ANDROLOGY
Citas Recibidas en Web of Science: 28
Documentos
- No hay documentos
Filiaciones
Keywords
- Delphi method; DNA fragmentation; Male infertility; Practice guidelines; Sperm; Survey
Cita
Agarwal A,Farkouh A,Saleh R,Hamoda T,Harraz AM,Kavoussi P,Arafa M,Salvio G,Rambhatla A,Toprak T,Gül M,Phuoc NHV,Boitrelle F,Birowo P,Abou R,Cannarella R,Kuroda S,Durairajanayagam D,Zini A,Wyns C,Sarikaya S,Tremellen K,Mostafa T,Sokolakis I,Evenson DP,Henkel R,Zohdy W,Chung E,Ziouziou I,Falcone M,Russo GI,Al M,Calogero AE,Ko E,Colpi G,Lewis S,Serefoglu EC,Bahar F,Martinez M,Nguyen Q,Ambar RF,Bakircioglu ME,Kandil H,Mogharabian N,Sabbaghian M,Taniguchi H,Tsujimura A,Sajadi H,Ibrahim W,Atmoko W,Vogiatzi P,Gunes S,Gilani M,Roychoudhury S,Güngör ND,Hakim L,Adriansjah R,Kothari P,Jindal S,Amar E,Park HJ,Long TQT,Homa S,Karthikeyan VS,Zilaitiene B,Rosas IM,Marino A,Pescatori E,Ozer C,Akhavizadegan H,GARRIDO N,Busetto GM,Adamyan A,Al M,Elbardisi H,Dolati P,Darbandi M,Darbandi S,Balercia G,Pinggera GM,Micic S,Ho CCK,Moussa M,Preto M,Zenoaga C,Smith RP,Kosgi R,de la Rosette J,El AI,Abumelha SM,Mierzwa TC,Ong TA,Banihani SA,Bowa K,Fukuhara S,Boeri L,Danacioglu YO,Gokalp F,Selim OM,Cho CL,Tadros NN,Ugur MR,Ozkent MS,Chiu P,Kalkanli A,Khalafalla K,Vishwakarma RB,Finocchi F,Andreadakis S,Giulioni C,Çeker G,Ceyhan E,Malhotra V,Yilmaz M,Timpano M,Barrett TL,Kim SHK,Ahn ST,Giacone F,Palani A,Duarsa GWK,Kadioglu A,Gadda F,Zylbersztejn DS,Aydos K,Kulaksiz D,Gupte D,Calik G,Karna KK,Drakopoulos P,Baser A,Kumar V,Molina JMC,Rajmil O,Ferreira RH,Leonardi S,Avoyan A,Sogutdelen E,Franco G,Ramsay J,Ramirez L,Shah R,Global F. Controversy and Consensus on Indications for Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations. World J. Men's Health. 2023. 41. (3):p. 575-602. IF:4,000. (1).