Portal de investigación
Role of miRNA-mRNA Interactome in Pathophysiology of Arrhythmogenic Cardiomyopathy
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Bonet, F
- Campuzano, O
- Cordoba-Caballero, J
- Alcalde, M
- Sarquella-Brugada, G
- Brugada, R
- Hernandez-Torres, F
- Quezada-Feijoo, M
- Ramos, M
- Mangas, A
- Ranea, JAG
- Toro, R
Grupos
Abstract
Arrhythmogenic cardiomyopathy is an inherited entity characterized by irregular cell-cell adhesion, cardiomyocyte death and fibro-fatty replacement of ventricular myocytes, leading to malignant ventricular arrythmias, contractile dysfunction and sudden cardiac death. Pathogenic variants in genes that encode desmosome are the predominant cause of arrhythmogenic cardiomyopathy. Moreover, signalling pathways such as Wnt/ss-catenin and transforming growth factor-beta have been involved in the disease progression. However, still little is known about the molecular pathophysiological mechanisms that underlie arrhythmogenic cardiomyopathy pathogenesis. We used mRNA and small RNA sequencing to analyse the transcriptome of health and arrhythmogenic cardiomyopathy of autopsied human hearts. Our results showed 697 differentially expressed genes and eight differentially expressed miRNAs. Functional enrichment revealed mitochondrial respiratory-related pathways, impaired response to oxidative stress, apoptotic signalling pathways and inflammatory response-related and extracellular matrix response pathways. Furthermore, analysis of the miRNA-mRNA interactome identified eleven negatively correlated miRNA-target pairs for arrhythmogenic cardiomyopathy. Our finding revealed novel arrhythmogenic cardiomyopathy-related miRNAs with important regulatory function in disease pathogenesis, highlighting their value as potential key targets for therapeutic approaches.
Datos de la publicación
- ISSN/ISSNe:
- 2227-9059, 2227-9059
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 39200271
- Factor de Impacto:
- 0,874 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Biomedicines MDPI
Citas Recibidas en Web of Science: 5
Documentos
- No hay documentos
Filiaciones
Keywords
- arrhythmogenic cardiomyopathy; sudden cardiac death; RNA sequencing; microRNA; miRNA-mRNA
Campos de Estudio
Proyectos y Estudios Clínicos
Are non-coding RNAs involved in the desestabilization of Wnt pathway in arrhythmogenic cardiomyopathy? Focus on epicardial adipose tissue.
Investigador Principal: AITANA BRAZA BOILS
PI21/01282 . INSTITUTO DE SALUD CARLOS III . 2022
Cita
Bonet F,Campuzano O,Cordoba J,Alcalde M,Sarquella G,BRAZA A,Brugada R,Hernandez F,Quezada M,Ramos M,Mangas A,Ranea J,Toro R. Role of miRNA-mRNA Interactome in Pathophysiology of Arrhythmogenic Cardiomyopathy. Biomedicines. 2024. 12. (8):1807. IF:3,900. (1).