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Rationale for combined therapies in severe-to-critical COVID-19 patients

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Gonzaga, A
  • Andreu, E
  • Hernández-Blasco, LM
  • Meseguer, R
  • Al-Akioui-Sanz, K
  • Soria-Juan, B
  • Sanjuan-Gimenez, JC
  • Ferreras, C
  • Tejedo, JR
  • Lopez-Lluch, G
  • Goterris, R
  • Maciá L
  • Sempere-Ortells, JM
  • Hmadcha, A
  • Borobia, A
  • Vicario, JL
  • Bonora, A
  • Arbona, C
  • Alenda, C
  • Tarín, F
  • Marco, FM
  • Merino, E
  • Jaime, F
  • Ferreres, J
  • Figueira, JC
  • Cañada-Illana, C
  • Querol, S
  • Eguizabal, C
  • Martin-Quirós, A
  • Robles-Marhuenda, A
  • Pérez-Martínez, A
  • Solano, C
  • Soria, B

Grupos

Abstract

An unprecedented global social and economic impact as well as a significant number of fatalities have been brought on by the coronavirus disease 2019 (COVID-19), produced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Acute SARS-CoV-2 infection can, in certain situations, cause immunological abnormalities, leading to an anomalous innate and adaptive immune response. While most patients only experience mild symptoms and recover without the need for mechanical ventilation, a substantial percentage of those who are affected develop severe respiratory illness, which can be fatal. The absence of effective therapies when disease progresses to a very severe condition coupled with the incomplete understanding of COVID-19's pathogenesis triggers the need to develop innovative therapeutic approaches for patients at high risk of mortality. As a result, we investigate the potential contribution of promising combinatorial cell therapy to prevent death in critical patients.

Datos de la publicación

ISSN/ISSNe:
1664-3224, 1664-3224

Frontiers in Immunology  FRONTIERS MEDIA SA

Tipo:
Review
Páginas:
-
PubMed:
37767093
Factor de Impacto:
2,331 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 3

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Keywords

  • COVID-19; cytokine storm; immunomodulation; mesenchymal stromal cells; SARS-CoV-2; advanced therapies

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