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Residual pulmonary infiltrates, symptoms and diffusion impairment at 1-year after severe COVID-19 infection have different associated factors

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Peces-Barba, G
  • Molina, M
  • España, PP
  • García, E
  • Consuegra-Vanegas, A
  • Pando-Sandoval, A
  • Panadero, C
  • Figueira-Gonçalves, JM
  • De la Rosa, D
  • Sibila, O
  • Martínez-Pitarch, MD
  • Toledo, N
  • Cejudo, P
  • Almonte-Batista, W
  • Macías-Paredes, A
  • Badenes, D
  • Pérez-Rodas, EN
  • Lázaro, J
  • Quirós, S
  • Cordovilla, R
  • Cano-Pumarega, I
  • Torres, A
  • RECOVID

Grupos

Abstract

Menendez R, Mendez R, Latorre A, Gonzalez-Jimenez P, Peces-Barba G, Molina M, et al. Residual pulmonary infiltrates, symptoms and diffusion impairment at 1-year after severe COVID-19 infection have different associated factors. J Intern Med. 2023;00:1-13. Introduction. After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, patients may show lung sequelae on radiology and functional impairment at the 1-year followup. We aimed to describe the persistence of symptoms, radiological alterations, or reduced diffusing capacity of the lung for carbon monoxide (DLCO) at 1-year follow-up in patients from the Spanish Registry RECOVID. Methods. RECOVID collected symptom and radiological and functional lung tests data on hospitalized patients with coronavirus disease 2019 during the acute phase and at the 6- and 12-month follow-up visits. Results. Of the 2500 enrolled survivors (90% admitted to the ward), 1874 had follow-up visits for up to a year. Of these, 42% continued to present with symptoms, 27% had radiological sequelae and 31% had reduced DLCO. Independently associated factors included female sex, asthma and the requirement for invasive or non-invasive mechanical ventilation. Complete radiological resolution was 72.2% at 12 months; associated factors with incomplete recovery were age, male sex, oxygen or respiratory support, corticosteroids and an initial SpO(2)/FiO(2) <450 or CURB-65 >= 2. Reduced D-LCO was observed in 31% of patients at 12 months; associated factors were older age, female sex, smoking habit, SpO(2)/FiO(2) <450 and CURB-65 >= 2 and the requirement of respiratory support.At 12 months, a proportion of the asymptomatic patients showed reduced D-LCO (9.5%), radiological findings (25%) or both (11%). Conclusions. The factors associated with symptom persistence, incomplete radiological resolution and D-LCO <80% differed according to age, sex, comorbidities and respiratory support. The burden of symptoms, reduced D-LCO and incomplete radiological resolution were considerable in patients with SARS-CoV-2 pneumonia at the 1-year follow-up after hospitalisation.

Datos de la publicación

ISSN/ISSNe:
0954-6820, 1365-2796

JOURNAL OF INTERNAL MEDICINE  WILEY

Tipo:
Article
Páginas:
69-82
PubMed:
37038609
Factor de Impacto:
3,193 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 8

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Keywords

  • COVID-19; RECOVID; SARS-CoV-2; SEPAR

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