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  3. Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration

Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Yu, QH
  • Walters, HE
  • Pasquini, G
  • Singh, SP
  • Lachnit, M
  • Oliveira, CR
  • León-Periñán, D
  • Petzold, A
  • Kesavan, P
  • Adrados, CS
  • Garteizgogeascoa, I
  • Knapp, D
  • Wagner, A
  • Bernardos, A
  • Alfonso, M
  • Nadar, G
  • Graf, AM
  • Troyanovskiy, KE
  • Dahl, A
  • Busskamp, V
  • Yun, MH

Grupos

Abstract

Axolotl limb regeneration is accompanied by the transient induction of cellular senescence within the blastema, the structure that nucleates regeneration. The precise role of this blastemal senescent cell (bSC) population, however, remains unknown. Here, through a combination of gain-and loss-of-function assays, we elucidate the functions and molecular features of cellular senescence in vivo. We demonstrate that cellular senescence plays a positive role during axolotl regeneration by creating a pro-proliferative niche that supports progenitor cell expansion and blastema outgrowth. Senescent cells impact their microenvironment via Wnt pathway modulation. Further, we identify a link between Wnt signaling and senescence induction and propose that bSC-derived Wnt signals facilitate the proliferation of neighboring cells in part by preventing their induction into senescence. This work defines the roles of cellular senescence in the regeneration of complex structures.

Datos de la publicación

ISSN/ISSNe:
1534-5807, 1878-1551

DEVELOPMENTAL CELL  CELL PRESS

Tipo:
Article
Páginas:
2416-
PubMed:
37879337
Factor de Impacto:
4,705 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 41

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