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Assemblable 3D biomimetic microenvironment for hMSC osteogenic differentiation

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Martins, LA
  • García-Parra, N
  • Ródenas-Rochina, J
  • Ribeiro, C
  • Lanceros-Méndez, S
  • Gómez-Ribelles, JL

Grupos

Abstract

Adequate simulation mimicking a tissue's native environment is one of the elemental premises in tissue engineering. Although various attempts have been made to induce human mesenchymal stem cells (hMSC) into an osteogenic pathway, they are still far from widespread clinical application. Most strategies focus primarily on providing a specific type of cue, inadequately replicating the complexity of the bone microenvironment. An alternative multifunctional platform for hMSC osteogenic differentiation has been produced. It is based on poly(vinylidene fluoride) (PVDF) and cobalt ferrites magnetoelectric microspheres, functionalized with collagen and gelatin, and packed in a 3D arrangement. This platform is capable of performing mechanical stimulation of piezoelectric PVDF, mimicking the bones electromechanical biophysical cues. Surface functionalization with extracellular matrix biomolecules and osteogenic medium complete this all-round approach. hMSC were cultured in osteogenic inducing conditions and tested for proliferation, surface biomarkers, and gene expression to evaluate their osteogenic commitment.

Datos de la publicación

ISSN/ISSNe:
1748-6041, 1748-605X

Biomedical Materials  IOP Publishing Ltd

Tipo:
Article
Páginas:
-
PubMed:
39303743
Factor de Impacto:
0,625 SCImago ℠
Cuartil:
Q2 SCImago ℠

Citas Recibidas en Web of Science: 2

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Keywords

  • biomimetic; tissue engineering; osteogenic pre-conditioning; smart materials; biophysical; biochemical; magnetoelectric

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