Portal de investigación
Delivery of miR-200c-3p Using Tumor-Targeted Mesoporous Silica Nanoparticles for Breast Cancer Therapy
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Garrido-Cano, I
- Adam-Artigues, A
- Lameirinhas, A
- Blandez, JF
- Candela-Noguera, V
- Lluch, A
- Bermejo, B
- Sancenón, F
- Cejalvo, JM
- Eroles, P
Grupos
Abstract
Despite advancesin breast cancer treatment, it remainsthe leadingcause of cancer-related death in women worldwide. In this context,microRNAs have emerged as potential therapeutic targets but stillpresent some limitations for in vivo applications.Particularly, miR-200c-3p is a well-known tumor suppressor microRNAthat inhibits tumor progression and metastasis in breast cancer throughdownregulating ZEB1 and ZEB2. Basedon the above, we describe the design and validation of a nanodeviceusing mesoporous silica nanoparticles for miR-200c-3p delivery forbreast cancer treatment. We demonstrate the biocompatibility of thesynthesized nanodevices as well as their ability to escape from endosomes/lysosomesand inhibit tumorigenesis, invasion, migration, and proliferationof tumor cells in vitro. Moreover, tumor targetingand effective delivery of miR-200c-3p from the nanoparticles in vivo are confirmed in an orthotopic breast cancer mousemodel, and the therapeutic efficacy is also evidenced by a decreasein tumor size and lung metastasis, while showing no signs of toxicity.Overall, our results provide evidence that miR-200c-3p-loaded nanoparticlesare a potential strategy for breast cancer therapy and a safe andeffective system for tumor-targeted delivery of microRNAs.
Datos de la publicación
- ISSN/ISSNe:
- 1944-8244, 1944-8252
- Tipo:
- Article
- Páginas:
- 38323-38334
- PubMed:
- 37549382
- Factor de Impacto:
- 2,143 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
ACS Applied Materials & Interfaces AMER CHEMICAL SOC
Citas Recibidas en Web of Science: 35
Documentos
- No hay documentos
Filiaciones
Keywords
- mesoporous silica nanoparticles; breast cancer; microRNA; therapy; targeted delivery
Cita
Garrido I,Adam A,Lameirinhas A,Blandez JF,Candela V,Lluch A,Bermejo B,Sancenón F,Cejalvo JM,MARTÍNEZ R,Eroles P. Delivery of miR-200c-3p Using Tumor-Targeted Mesoporous Silica Nanoparticles for Breast Cancer Therapy. ACS Appl. Mater. Interfaces. 2023. 15. (32):p. 38323-38334. IF:8,500. (1).