1. Inicio
  2. Publicaciones
  3. Insights from a 7-Year Dementia Cohort (VALCODIS): ApoE Genotype Evaluation

Insights from a 7-Year Dementia Cohort (VALCODIS): ApoE Genotype Evaluation

Fecha de publicación:

Autores de IIS La Fe

Grupos

Abstract

Background: The VALCODIS (Valencian Cognitive Diseases Study) cohort was designed and studied at the Hospital Universitari i Polit & egrave;cnic La Fe (Valencia, Spain) for the research of cognitive diseases, especially in the search for new biomarkers of Alzheimer's disease (AD). Methods: Participants in the VALCODIS cohort had cerebrospinal fluid (CSF) and blood samples, neuroimaging, and neuropsychological tests. The ApoE genotype was evaluated to identify its relationship with CSF biomarkers and neuropsychological tests in AD and non-AD participants. Results: A total of 1249 participants were included. They were mainly AD patients (n = 547) but also patients with other dementias (frontotemporal lobar dementia (n = 61), Lewy body dementia without AD CSF signature (n = 10), vascular dementia (n = 24) and other specific causes of cognitive impairment (n = 442), and patients with subjective memory complaints (n = 165)). In the ApoE genotype evaluation, significant differences were found for A beta 42 levels between genotypes in both AD and non-AD patients, as well as a negative correlation between tau values and a cognitive test in non-carriers and epsilon 4 heterozygous. Conclusions: The VALCODIS cohort provides biologically diagnosed patients with demographical, clinical and biochemical data, and biological samples for further studies on early AD diagnosis. Also, the ApoE genotype evaluation showed correlations between CSF biomarkers and neuropsychological tests.

Datos de la publicación

ISSN/ISSNe:
2077-0383, 2077-0383

Journal of Clinical Medicine  MDPI

Tipo:
Article
Páginas:
-
PubMed:
39200877
Factor de Impacto:
1,040 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 7

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Keywords

  • cognitive disease; dementia; Alzheimer's; biomarkers; neuropsychology; ApoE

Campos de Estudio

Proyectos y Estudios Clínicos

Contratos Miguel Servet II 2021. Consuelo Cháfer.

Investigador Principal: MARÍA CONSUELO CHÁFER PERICÁS

CPII21/00006 . INSTITUTO DE SALUD CARLOS III . 2022

Diagnóstico y pronóstico de la Enfermedad de Alzheimer asintomática y sintomática temprana: metilómica del ADN y proteómica.

Investigador Principal: MARÍA CONSUELO CHÁFER PERICÁS

PI22/00594 . INSTITUTO DE SALUD CARLOS III . 2023

Compartir