1. Inicio
  2. Publicaciones
  3. Assessment of SARS-CoV-2 neutralizing from convalescent and vaccinated mothers

Assessment of SARS-CoV-2 neutralizing from convalescent and vaccinated mothers

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Bäuerl, C
  • Zulaica, J
  • Rusu, L
  • Moreno, AR
  • Pérez-Cano, FJ
  • Lerin, C
  • Mena-Tudela, D
  • Aguilar-Camprubí, L
  • Martínez-Costa, C
  • Geller, R
  • Collado, MC
  • MilkCORONA Study Team

Grupos

Abstract

Breastmilk contains antibodies that could protect breastfed infants from infec-tions. In this work, we examined if antibodies in breastmilk could neutralize SARS-CoV-2 in 84 breastmilk samples from women that were either vaccinated (Comirnaty, mRNA-1273, or ChAdOx1), infected with SARS-CoV-2, or both in-fected and vaccinated. The neutralization capacity of these sera was tested using pseudotyped vesicular stomatitis virus carrying either the Wuhan-Hu-1, Delta, or BA.1 Omicron spike proteins. We found that natural infection resulted in higher neutralizing titers and that neutralization correlated positively with levels of immunoglobulin A in breastmilk. In addition, significant differences in the capac-ity to produce neutralizing antibodies were observed between both mRNA-based vaccines and the adenovirus-vectored ChAdOx1 COVID-19 vaccine. Over-all, our results indicate that breastmilk from naturally infected women or those vaccinated with mRNA-based vaccines contains SARS-CoV-2 neutralizing anti-bodies that could potentially provide protection to breastfed infants from infec-tion.

Datos de la publicación

ISSN/ISSNe:
2589-0042, 2589-0042

iScience  CELL PRESS

Tipo:
Article
Páginas:
-
PubMed:
37197591
Factor de Impacto:
1,592 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 4

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Campos de Estudio

Cita

Compartir