Portal de investigación
Basic host response parameters to classify mortality risk in COVID-19 and community-acquired pneumonia
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Zalacain, R
- Ruiz, LA
- Serrano, L
- España, PP
- Uranga, A
- Cillóniz, C
- Gaetano-Gil, A
- Fernández-Félix, BM
- Pérez-de-Llano, L
- Golpe, R
- Torres, A
Grupos
Abstract
Improved phenotyping in pneumonia is necessary to strengthen risk assessment. Via a feasible and multidimensional approach with basic parameters, we aimed to evaluate the effect of host response at admission on severity stratification in COVID-19 and community-acquired pneumonia (CAP). Three COVID-19 and one CAP multicenter cohorts including hospitalized patients were recruited. Three easily available variables reflecting different pathophysiologic mechanisms-immune, inflammation, and respiratory-were selected (absolute lymphocyte count [ALC], C-reactive protein [CRP] and, SpO(2)/FiO(2)). In-hospital mortality and intensive care unit (ICU) admission were analyzed as outcomes. A multivariable, penalized maximum likelihood logistic regression was performed with ALC (< 724 lymphocytes/mm(3)), CRP (> 60 mg/L), and, SpO(2)/FiO(2) (< 450). A total of 1452, 1222 and 462 patients were included in the three COVID-19 and 1292 in the CAP cohort for the analysis. Mortality ranged between 4 and 32% (0 to 3 abnormal biomarkers) and 0-9% in SARS-CoV-2 pneumonia and CAP, respectively. In the first COVID-19 cohort, adjusted for age and sex, we observed an increased odds ratio for in-hospital mortality in COVID-19 with elevated biomarkers altered (OR 1.8, 3, and 6.3 with 1, 2, and 3 abnormal biomarkers, respectively). The model had an AUROC of 0.83. Comparable findings were found for ICU admission, with an AUROC of 0.76. These results were confirmed in the other COVID-19 cohorts Similar OR trends were reported in the CAP cohort; however, results were not statistically significant. Assessing the host response via accessible biomarkers is a simple and rapidly applicable approach for pneumonia.
Datos de la publicación
- ISSN/ISSNe:
- 2045-2322, 2045-2322
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 38830925
- Factor de Impacto:
- 1,005 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Scientific Reports NATURE PORTFOLIO
Citas Recibidas en Web of Science: 2
Documentos
- No hay documentos
Filiaciones
Keywords
- COVID-19; Pneumonia; Host response; Biomarkers; Mortality
Campos de Estudio
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Cita
MENÉNDEZ R,MÉNDEZ R,GONZÁLEZ P,LATORRE A,REYES S,Zalacain R,Ruiz LA,Serrano L,España PP,Uranga A,Cillóniz C,Gaetano A,Fernández BM,Pérez L,Golpe R,Torres A. Basic host response parameters to classify mortality risk in COVID-19 and community-acquired pneumonia. Sci. Rep. 2024. 14. (1):12726. IF:3,900. (1).