PGT-HLA programmes for the cure of a sick sibling: clinical strategies for this challenging search

Autores de IIS La Fe

• Cinzia Caligara

  Autor

• Esther Santamaría López

  Autor

• María José Hernáez Silva

  Autor

• Ana Ortiz Vallecillo

  Autor

• Myriam Ruíz Pérez

  Autor

• Nicolás Prados Dodd

  Autor

• Cristina María González Ravina

  Autor

• Manuel Fernández Sánchez

  Autor

Grupos

• Biología Reproductiva y Bioingeniería en Reproducción Humana

• Biomarcadores, Medicina Genómica, Estadística y Análisis masivo de datos en Reproducción humana asistida

• Endocrinología Reproductiva e Infertilidad

Abstract

The ultimate goal of a preimplantation genetic testing and human leukocyte antigen (PGT-HLA) matching programme is the birth of a healthy, HLA-compatible child for the treatment or cure of a sick sibling. Several authors have published successful cases of the births of children HLA-matched to siblings affected by different conditions and diseases. However, there are many reports of failed attempts. Couples seeking an HLA-matched sibling for their affected child look for positive outcomes in the shortest possible time. Nevertheless, there is no published consensus or guidelines with recommendations for these cases. Here, the authors aimed to analyse different approaches for these programmes, highlighting the most promising strategies for the families and fertility units. Furthermore, the authors mention a successful case of a PGT-HLA matching programme after a previous failed attempt following the strategies proposed. Which is the most cost-effective and time-efficient approach in a PGT-HLA matching programme?

Keywords

• Blastocyst biopsy; Diamond-Blackfan anaemia; PGT-HLA; Preimplantation genetic testing; Preimplantation HLA typing; Trophectoderm biopsy